chr12 : 21,600,100 – 21,600,738

638 bp 65 TFs 1 linked gene

This 638 bp open chromatin element is linked to GYS2 and is bound by 65 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
GYS2		4.1 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

65 transcription factors

BCL11A 1 dataset

ChIP CD34_Day3_30min GSE104676.BCL11A.CD34_Day3_30min 56 bp overlap

CEBPA 1 dataset

ChIP Kasumi-1_CEBPA-ER GSE102697.CEBPA.Kasumi-1_CEBPA-ER 95 bp overlap

EOMES 3 datasets

Motif DE_36h DE_36h-EOMES_MA0800.2 9 bp overlap

Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 281 bp overlap

ERF::FOXI1 1 dataset

Motif DE_36h DE_36h-ERFFOXI1_MA1935.2 10 bp overlap

ERG 1 dataset

ChIP aortic-endothelial-cell_D5 GSE139377.ERG.aortic-endothelial-cell_D5 147 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_36h DE_36h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::FOXI1 1 dataset

Motif DE_36h DE_36h-ETV5FOXI1_MA1946.2 12 bp overlap

FEZF2 2 datasets

Motif DE_36h DE_36h-FEZF2_MA2341.1 8 bp overlap

Motif DE_60h DE_60h-FEZF2_MA2341.1 8 bp overlap

FIGLA 2 datasets

Motif DE_36h DE_36h-FIGLA_MA0820.2 6 bp overlap

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_36h DE_36h-FLI1FOXI1_MA1950.2 11 bp overlap

FOSL2 2 datasets

Motif DE_36h DE_36h-FOSL2_MA0478.2 10 bp overlap

Motif DE_60h DE_60h-FOSL2_MA0478.2 10 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 584 bp overlap

ChIP DE DE-FOXA2-2 638 bp overlap

FOXJ2::ELF1 1 dataset

Motif DE_36h DE_36h-FOXJ2ELF1_MA1952.2 11 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_36h DE_36h-FOXO1ELK1_MA1954.2 13 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 589 bp overlap

ChIP DE DE-GATA4-2 579 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 541 bp overlap

ChIP DE DE-GATA6-2 575 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 284 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 421 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 501 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 532 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 463 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 420 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 351 bp overlap

GLIS1 1 dataset

Motif DE_36h DE_36h-GLIS1_MA0735.2 15 bp overlap

GLIS2 1 dataset

Motif DE_36h DE_36h-GLIS2_MA0736.1 14 bp overlap

GLIS3 1 dataset

Motif DE_36h DE_36h-GLIS3_MA0737.1 14 bp overlap

IKZF1 1 dataset

Motif DE_36h DE_36h-IKZF1_MA1508.2 8 bp overlap

IKZF2 1 dataset

Motif DE_36h DE_36h-IKZF2_MA2326.1 6 bp overlap

MGA 2 datasets

Motif DE_36h DE_36h-MGA_MA0801.1 8 bp overlap

Motif DE_60h DE_60h-MGA_MA0801.1 8 bp overlap

MGA::EVX1 2 datasets

Motif DE_36h DE_36h-MGAEVX1_MA1960.2 11 bp overlap

Motif DE_60h DE_60h-MGAEVX1_MA1960.2 11 bp overlap

MYCN 1 dataset

ChIP Kelly_res GSE115249.MYCN.Kelly_res 129 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 378 bp overlap

Nr5A2 2 datasets

Motif DE_36h DE_36h-Nr5A2_MA0505.3 9 bp overlap

Motif DE_60h DE_60h-Nr5A2_MA0505.3 9 bp overlap

PBX1 1 dataset

Motif DE_36h DE_36h-PBX1_MA0070.2 9 bp overlap

PKNOX2 2 datasets

Motif DE_36h DE_36h-PKNOX2_MA0783.1 12 bp overlap

Motif DE_60h DE_60h-PKNOX2_MA0783.1 12 bp overlap

PRDM9 1 dataset

Motif DE_36h DE_36h-PRDM9_MA1723.2 20 bp overlap

Prdm5 1 dataset

Motif DE_36h DE_36h-Prdm5_MA1999.2 11 bp overlap

Ptf1A 2 datasets

Motif DE_36h DE_36h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_60h DE_60h-Ptf1A_MA1620.2 8 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 362 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 319 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 369 bp overlap

SNAI2 4 datasets

Motif DE_36h DE_36h-SNAI2_MA0745.3 8 bp overlap

Motif DE_60h DE_60h-SNAI2_MA0745.3 8 bp overlap

ChIP SMS-CTR_D48 GSE137168.SNAI2.SMS-CTR_D48 295 bp overlap

ChIP SMS-CTR_shSNAI2 GSE137168.SNAI2.SMS-CTR_shSNAI2 191 bp overlap

SNAI3 2 datasets

Motif DE_36h DE_36h-SNAI3_MA1559.2 9 bp overlap

Motif DE_60h DE_60h-SNAI3_MA1559.2 9 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 338 bp overlap

SPIB 1 dataset

Motif DE_36h DE_36h-SPIB_MA0081.3 13 bp overlap

SPIC 1 dataset

Motif DE_36h DE_36h-SPIC_MA0687.2 13 bp overlap

Sox11 1 dataset

Motif DE_36h DE_36h-Sox11_MA0869.3 8 bp overlap

Spi1 1 dataset

Motif DE_36h DE_36h-Spi1_MA0080.7 13 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 187 bp overlap

TBR1 2 datasets

Motif DE_36h DE_36h-TBR1_MA0802.2 9 bp overlap

Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap

TBX1 2 datasets

Motif DE_36h DE_36h-TBX1_MA0805.1 8 bp overlap

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

TBX15 2 datasets

Motif DE_36h DE_36h-TBX15_MA0803.1 8 bp overlap

Motif DE_60h DE_60h-TBX15_MA0803.1 8 bp overlap

TBX18 3 datasets

Motif DE_36h DE_36h-TBX18_MA1565.2 9 bp overlap

Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap

TBX2 2 datasets

Motif DE_36h DE_36h-TBX2_MA0688.2 9 bp overlap

Motif DE_60h DE_60h-TBX2_MA0688.2 9 bp overlap

TBX20 2 datasets

Motif DE_36h DE_36h-TBX20_MA0689.1 11 bp overlap

Motif DE_60h DE_60h-TBX20_MA0689.1 11 bp overlap

TBX21 2 datasets

Motif DE_36h DE_36h-TBX21_MA0690.3 10 bp overlap

Motif DE_60h DE_60h-TBX21_MA0690.3 10 bp overlap

TBX3 2 datasets

Motif DE_36h DE_36h-TBX3_MA1566.3 9 bp overlap

Motif DE_60h DE_60h-TBX3_MA1566.3 9 bp overlap

TBX4 2 datasets

Motif DE_36h DE_36h-TBX4_MA0806.1 8 bp overlap

Motif DE_60h DE_60h-TBX4_MA0806.1 8 bp overlap

TBX5 2 datasets

Motif DE_36h DE_36h-TBX5_MA0807.1 8 bp overlap

Motif DE_60h DE_60h-TBX5_MA0807.1 8 bp overlap

TGIF1 2 datasets

Motif DE_36h DE_36h-TGIF1_MA0796.1 12 bp overlap

Motif DE_60h DE_60h-TGIF1_MA0796.1 12 bp overlap

TGIF2 2 datasets

Motif DE_36h DE_36h-TGIF2_MA0797.1 12 bp overlap

Motif DE_60h DE_60h-TGIF2_MA0797.1 12 bp overlap

Tbx6 2 datasets

Motif DE_36h DE_36h-Tbx6_MA1567.3 9 bp overlap

Motif DE_60h DE_60h-Tbx6_MA1567.3 9 bp overlap

VEZF1 1 dataset

Motif DE_36h DE_36h-VEZF1_MA1578.2 6 bp overlap

ZBTB18 2 datasets

Motif DE_36h DE_36h-ZBTB18_MA0698.2 11 bp overlap

Motif DE_60h DE_60h-ZBTB18_MA0698.2 11 bp overlap

ZEB1 2 datasets

Motif DE_36h DE_36h-ZEB1_MA0103.4 6 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

ZNF184 1 dataset

Motif DE_36h DE_36h-ZNF184_MA2120.1 13 bp overlap

ZNF257 2 datasets

Motif DE_36h DE_36h-ZNF257_MA1710.2 10 bp overlap

Motif DE_60h DE_60h-ZNF257_MA1710.2 10 bp overlap

ZNF281 1 dataset

Motif DE_36h DE_36h-ZNF281_MA1630.3 10 bp overlap

ZNF701 1 dataset

Motif DE_36h DE_36h-ZNF701_MA1987.2 17 bp overlap

ZNF708 2 datasets

Motif DE_36h DE_36h-ZNF708_MA1730.2 9 bp overlap

Motif DE_60h DE_60h-ZNF708_MA1730.2 9 bp overlap

ZNF740 1 dataset

Motif DE_36h DE_36h-ZNF740_MA0753.3 10 bp overlap

ZNF75A 1 dataset

Motif DE_36h DE_36h-ZNF75A_MA2097.1 12 bp overlap

ZNF85 2 datasets

Motif DE_36h DE_36h-ZNF85_MA1720.2 12 bp overlap

Motif DE_60h DE_60h-ZNF85_MA1720.2 12 bp overlap