chr4 : 127,777,959 – 127,778,503

544 bp 60 TFs 1 linked gene

This 544 bp open chromatin element is linked to HSPA4L and is bound by 60 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
HSPA4L		3.8 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

60 transcription factors

ASCL1 2 datasets

Motif DE_48h DE_48h-ASCL1_MA1100.3 8 bp overlap

Motif DE_48h DE_48h-ASCL1_MA1631.2 9 bp overlap

CBFA2T3 1 dataset

ChIP K562 ENCFF673OEZ 411 bp overlap

ERF::FIGLA 1 dataset

Motif DE_48h DE_48h-ERFFIGLA_MA1934.2 13 bp overlap

ERF::FOXO1 1 dataset

Motif DE_48h DE_48h-ERFFOXO1_MA1936.2 12 bp overlap

FEZF2 1 dataset

Motif DE_48h DE_48h-FEZF2_MA2341.1 8 bp overlap

FIGLA 1 dataset

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 411 bp overlap

ChIP DE DE-FOXA2-2 376 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap

GATA2 1 dataset

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 382 bp overlap

ChIP DE DE-GATA4-2 334 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 544 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 524 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 314 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 386 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 372 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 329 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 398 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 282 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 408 bp overlap

Gata3 1 dataset

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

IKZF2 1 dataset

ChIP GM12878 ENCFF918AID 326 bp overlap

MEF2A 1 dataset

Motif DE_48h DE_48h-MEF2A_MA0052.5 10 bp overlap

MEF2C 1 dataset

Motif DE_48h DE_48h-MEF2C_MA0497.2 11 bp overlap

Msgn1 1 dataset

Motif DE_48h DE_48h-Msgn1_MA1524.3 10 bp overlap

NFIA 1 dataset

Motif DE_48h DE_48h-NFIA_MA0670.2 6 bp overlap

NFIB 1 dataset

Motif DE_48h DE_48h-NFIB_MA1643.2 17 bp overlap

NFIC 1 dataset

Motif DE_48h DE_48h-NFIC_MA1527.2 15 bp overlap

NFIC::TLX1 1 dataset

Motif DE_48h DE_48h-NFICTLX1_MA0119.1 14 bp overlap

NFIX 2 datasets

Motif DE_48h DE_48h-NFIX_MA0671.2 6 bp overlap

Motif DE_48h DE_48h-NFIX_MA1528.2 14 bp overlap

NFYA 1 dataset

Motif DE_48h DE_48h-NFYA_MA0060.4 8 bp overlap

NFYC 1 dataset

Motif DE_48h DE_48h-NFYC_MA1644.2 7 bp overlap

NR3C1 1 dataset

Motif DE_48h DE_48h-NR3C1_MA0113.4 15 bp overlap

NR3C2 1 dataset

Motif DE_48h DE_48h-NR3C2_MA0727.2 15 bp overlap

OSR1 1 dataset

Motif DE_48h DE_48h-OSR1_MA1542.2 8 bp overlap

OSR2 1 dataset

Motif DE_48h DE_48h-OSR2_MA1646.2 8 bp overlap

PBX2 2 datasets

ChIP Hep-G2 ENCSR849DFF.PBX2.Hep-G2 161 bp overlap

ChIP HepG2 ENCFF225AJT 365 bp overlap

PBX3 1 dataset

Motif DE_48h DE_48h-PBX3_MA1114.2 11 bp overlap

PKNOX1 7 datasets

Motif DE_48h DE_48h-PKNOX1_MA0782.3 10 bp overlap

ChIP GM12878 ENCFF589FCY 290 bp overlap

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 342 bp overlap

ChIP HEK293T ENCFF174WDB 175 bp overlap

ChIP HEK293T ENCSR233FAG.PKNOX1.HEK293T 216 bp overlap

ChIP K-562 ENCSR115SMW.PKNOX1.K-562 343 bp overlap

ChIP K562 ENCFF236IUS 373 bp overlap

POU2F3 1 dataset

ChIP NCI-H1048 GSE115123.POU2F3.NCI-H1048 313 bp overlap

PRDM10 3 datasets

ChIP HEK293 ENCFF145WQQ 140 bp overlap

ChIP K-562 ENCSR120MPG.PRDM10.K-562 56 bp overlap

ChIP K562 ENCFF740YLK 177 bp overlap

Pgr 2 datasets

Motif DE_48h DE_48h-Pgr_MA2323.1 17 bp overlap

SNAI1 1 dataset

Motif DE_48h DE_48h-SNAI1_MA1558.2 7 bp overlap

SNAI2 1 dataset

Motif DE_48h DE_48h-SNAI2_MA0745.3 8 bp overlap

SNAI3 1 dataset

Motif DE_48h DE_48h-SNAI3_MA1559.2 9 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 289 bp overlap

SOX6 2 datasets

ChIP K562 ENCFF059YCJ 437 bp overlap

ChIP K562 ENCFF059YCJ 265 bp overlap

SP5 1 dataset

Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap

SPIC 1 dataset

Motif DE_48h DE_48h-SPIC_MA0687.2 13 bp overlap

Sox11 1 dataset

Motif DE_48h DE_48h-Sox11_MA0869.3 8 bp overlap

Sox17 1 dataset

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Sox6 1 dataset

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Sox7 1 dataset

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

Stat5a::Stat5b 1 dataset

Motif DE_48h DE_48h-Stat5aStat5b_MA0519.2 9 bp overlap

TAL1 3 datasets

ChIP K-562 GSE107726.TAL1.K-562 168 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 182 bp overlap

ChIP K562 ENCFF661CCK 277 bp overlap

TCF12 1 dataset

Motif DE_48h DE_48h-TCF12_MA1648.2 7 bp overlap

TCF3 1 dataset

Motif DE_48h DE_48h-TCF3_MA0522.4 7 bp overlap

TCF4 1 dataset

Motif DE_48h DE_48h-TCF4_MA0830.3 8 bp overlap

TRPS1 1 dataset

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

ZEB1 1 dataset

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

ZNF213 2 datasets

Motif DE_48h DE_48h-ZNF213_MA2121.1 12 bp overlap

ZNF263 1 dataset

Motif DE_48h DE_48h-ZNF263_MA0528.3 7 bp overlap

ZNF354A 1 dataset

Motif DE_48h DE_48h-ZNF354A_MA1978.2 20 bp overlap

ZNF416 1 dataset

Motif DE_48h DE_48h-ZNF416_MA1979.2 10 bp overlap

ZNF680 1 dataset

Motif DE_48h DE_48h-ZNF680_MA1729.2 11 bp overlap

ZNF684 1 dataset

Motif DE_48h DE_48h-ZNF684_MA1600.2 14 bp overlap

ZNF701 1 dataset

Motif DE_48h DE_48h-ZNF701_MA1987.2 17 bp overlap

ZNF708 1 dataset

Motif DE_48h DE_48h-ZNF708_MA1730.2 9 bp overlap

Zfp335 1 dataset

Motif DE_48h DE_48h-Zfp335_MA2002.2 7 bp overlap