chr2 : 221,931,292 – 221,931,996

704 bp 67 TFs 1 linked gene

This 704 bp open chromatin element is linked to EPHA4 and is bound by 67 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
EPHA4		359.2 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

67 transcription factors

BCL11A 1 dataset

Motif DE_48h DE_48h-BCL11A_MA2324.1 7 bp overlap

EGR1 1 dataset

ChIP fibroblast_DOX-24h GSE134924.EGR1.fibroblast_DOX-24h 205 bp overlap

EHF 1 dataset

Motif DE_48h DE_48h-EHF_MA0598.4 9 bp overlap

ELF1 1 dataset

Motif DE_48h DE_48h-ELF1_MA0473.4 9 bp overlap

ELF3 1 dataset

Motif DE_48h DE_48h-ELF3_MA0640.3 9 bp overlap

ELK4 1 dataset

Motif DE_48h DE_48h-ELK4_MA0076.3 9 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 304 bp overlap

ERF 1 dataset

Motif DE_48h DE_48h-ERF_MA0760.2 9 bp overlap

ERF::FOXI1 1 dataset

Motif DE_48h DE_48h-ERFFOXI1_MA1935.2 10 bp overlap

ERG 1 dataset

ChIP VCaP GSE49091.ERG.VCaP 133 bp overlap

ETS1 1 dataset

Motif DE_48h DE_48h-ETS1_MA0098.4 9 bp overlap

ETV1 1 dataset

Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap

ETV2 1 dataset

Motif DE_48h DE_48h-ETV2_MA0762.2 9 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_48h DE_48h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::FOXO1 1 dataset

Motif DE_48h DE_48h-ETV5FOXO1_MA1947.2 10 bp overlap

EWSR1-FLI1 2 datasets

Motif DE_48h DE_48h-EWSR1-FLI1_MA0149.1 18 bp overlap

Motif DE_72h DE_72h-EWSR1-FLI1_MA0149.1 18 bp overlap

Erg 1 dataset

Motif DE_48h DE_48h-Erg_MA0474.4 10 bp overlap

FLI1 1 dataset

Motif DE_48h DE_48h-FLI1_MA0475.3 9 bp overlap

FLI1::DRGX 1 dataset

Motif DE_48h DE_48h-FLI1DRGX_MA1949.2 14 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_48h DE_48h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA1 4 datasets

Motif DE_36h DE_36h-FOXA1_MA0148.5 8 bp overlap

Motif DE_48h DE_48h-FOXA1_MA0148.5 8 bp overlap

Motif DE_72h DE_72h-FOXA1_MA0148.5 8 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 213 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 679 bp overlap

ChIP DE DE-FOXA2-2 668 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 192 bp overlap

FOXB1 3 datasets

Motif DE_36h DE_36h-FOXB1_MA0845.1 11 bp overlap

Motif DE_48h DE_48h-FOXB1_MA0845.1 11 bp overlap

Motif DE_72h DE_72h-FOXB1_MA0845.1 11 bp overlap

FOXC1 3 datasets

Motif DE_36h DE_36h-FOXC1_MA0032.2 11 bp overlap

Motif DE_48h DE_48h-FOXC1_MA0032.2 11 bp overlap

Motif DE_72h DE_72h-FOXC1_MA0032.2 11 bp overlap

FOXC2 3 datasets

Motif DE_36h DE_36h-FOXC2_MA0846.2 11 bp overlap

Motif DE_48h DE_48h-FOXC2_MA0846.2 11 bp overlap

Motif DE_72h DE_72h-FOXC2_MA0846.2 11 bp overlap

FOXJ2::ELF1 1 dataset

Motif DE_48h DE_48h-FOXJ2ELF1_MA1952.2 11 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::ELK3 1 dataset

Motif DE_48h DE_48h-FOXO1ELK3_MA1955.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_48h DE_48h-FOXO1FLI1_MA1956.2 13 bp overlap

FOXO6 3 datasets

Motif DE_36h DE_36h-FOXO6_MA0849.1 7 bp overlap

Motif DE_48h DE_48h-FOXO6_MA0849.1 7 bp overlap

Motif DE_72h DE_72h-FOXO6_MA0849.1 7 bp overlap

Foxl2 3 datasets

Motif DE_36h DE_36h-Foxl2_MA1607.2 10 bp overlap

Motif DE_48h DE_48h-Foxl2_MA1607.2 10 bp overlap

Motif DE_72h DE_72h-Foxl2_MA1607.2 10 bp overlap

GABPA 1 dataset

Motif DE_48h DE_48h-GABPA_MA0062.4 10 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 704 bp overlap

ChIP DE DE-GATA4-2 704 bp overlap

ChIP foregut GSE117136.GATA4.foregut 358 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 391 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 241 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 300 bp overlap

GATA6 6 datasets

ChIP DE DE-GATA6-1 704 bp overlap

ChIP DE DE-GATA6-2 704 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 434 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 537 bp overlap

ChIP foregut GSE117136.GATA6.foregut 334 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 257 bp overlap

HOXB2::ELK1 1 dataset

Motif DE_48h DE_48h-HOXB2ELK1_MA1957.1 14 bp overlap

Hoxd13 3 datasets

Motif DE_36h DE_36h-Hoxd13_MA0909.4 7 bp overlap

Motif DE_48h DE_48h-Hoxd13_MA0909.4 7 bp overlap

Motif DE_72h DE_72h-Hoxd13_MA0909.4 7 bp overlap

IKZF1 1 dataset

Motif DE_48h DE_48h-IKZF1_MA1508.2 8 bp overlap

Ikzf3 1 dataset

Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap

KLF5 3 datasets

Motif DE_36h DE_36h-KLF5_MA0599.1 10 bp overlap

Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap

Motif DE_72h DE_72h-KLF5_MA0599.1 10 bp overlap

MAFF 1 dataset

ChIP HepG2 ENCFF452YUT 277 bp overlap

MAFK 4 datasets

ChIP A549 ENCFF371EPR 381 bp overlap

ChIP Hep-G2 ENCSR000EDZ.MAFK.Hep-G2 182 bp overlap

ChIP HepG2 ENCFF743ZOF 241 bp overlap

ChIP HepG2 ENCFF767LDG 257 bp overlap

MAZ 3 datasets

Motif DE_36h DE_36h-MAZ_MA1522.2 8 bp overlap

Motif DE_48h DE_48h-MAZ_MA1522.2 8 bp overlap

Motif DE_72h DE_72h-MAZ_MA1522.2 8 bp overlap

MEIS1 3 datasets

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MYOG 1 dataset

ChIP RH4_Entinostat-6H GSE116344.MYOG.RH4_Entinostat-6H 304 bp overlap

Mecom 3 datasets

Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap

Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap

Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap

NEUROG2 1 dataset

ChIP MRC-5_N_05DPT GSE75910.NEUROG2.MRC-5_N_05DPT 186 bp overlap

NFATC3 2 datasets

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

NFATC4 2 datasets

Motif DE_48h DE_48h-NFATC4_MA1525.3 9 bp overlap

Motif DE_72h DE_72h-NFATC4_MA1525.3 9 bp overlap

Nfatc1 2 datasets

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

PDX1 1 dataset

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 413 bp overlap

Prdm4 2 datasets

Motif DE_48h DE_48h-Prdm4_MA1647.3 11 bp overlap

Motif DE_72h DE_72h-Prdm4_MA1647.3 11 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 651 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 234 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 334 bp overlap

SOX10 1 dataset

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 584 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 593 bp overlap

SP4 3 datasets

Motif DE_36h DE_36h-SP4_MA0685.2 9 bp overlap

Motif DE_48h DE_48h-SP4_MA0685.2 9 bp overlap

Motif DE_72h DE_72h-SP4_MA0685.2 9 bp overlap

SP5 2 datasets

Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

SPIB 1 dataset

Motif DE_48h DE_48h-SPIB_MA0081.3 13 bp overlap

Spi1 1 dataset

Motif DE_48h DE_48h-Spi1_MA0080.7 13 bp overlap

ZFP57 1 dataset

Motif DE_48h DE_48h-ZFP57_MA1583.2 7 bp overlap

ZKSCAN5 2 datasets

Motif DE_48h DE_48h-ZKSCAN5_MA1652.2 9 bp overlap

Motif DE_72h DE_72h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF148 3 datasets

Motif DE_36h DE_36h-ZNF148_MA1653.2 10 bp overlap

Motif DE_48h DE_48h-ZNF148_MA1653.2 10 bp overlap

Motif DE_72h DE_72h-ZNF148_MA1653.2 10 bp overlap

ZNF175 1 dataset

Motif DE_48h DE_48h-ZNF175_MA2332.1 9 bp overlap

ZNF558 1 dataset

Motif DE_48h DE_48h-ZNF558_MA2335.1 29 bp overlap

ZNF585A 1 dataset

ChIP HEK293T GSE78099.ZNF585A.HEK293T 226 bp overlap