chr5 : 54,872,603 – 54,873,437

834 bp 57 TFs 2 linked genes

This 834 bp open chromatin element is linked to GPX8 and SNX18 and is bound by 57 transcription factors.

Linked Genes

2 genes

Gene	Expression	Dist. to TSS	Distance	Link type
GPX8		287.2 kb	Distal	Multiome+HiCAR
SNX18		355.3 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

57 transcription factors

BHLHE22 1 dataset

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

BRD4 1 dataset

ChIP hESC GSE33281.BRD4.hESC 61 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF093OYK 179 bp overlap

ChIP BLaER1 ENCFF093OYK 394 bp overlap

DUX4 2 datasets

Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap

Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap

EHF 2 datasets

Motif DE_48h DE_48h-EHF_MA0598.4 9 bp overlap

Motif DE_60h DE_60h-EHF_MA0598.4 9 bp overlap

ELF1 2 datasets

Motif DE_48h DE_48h-ELF1_MA0473.4 9 bp overlap

Motif DE_60h DE_60h-ELF1_MA0473.4 9 bp overlap

ELK1::SREBF2 2 datasets

Motif DE_48h DE_48h-ELK1SREBF2_MA1933.2 15 bp overlap

Motif DE_60h DE_60h-ELK1SREBF2_MA1933.2 15 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 441 bp overlap

ChIP hESC GSE26097.EOMES.hESC 293 bp overlap

ERF::FOXI1 1 dataset

Motif DE_36h DE_36h-ERFFOXI1_MA1935.2 10 bp overlap

ERF::FOXO1 1 dataset

Motif DE_36h DE_36h-ERFFOXO1_MA1936.2 12 bp overlap

ETV3 1 dataset

Motif DE_48h DE_48h-ETV3_MA0763.2 9 bp overlap

ETV5::FOXI1 1 dataset

Motif DE_36h DE_36h-ETV5FOXI1_MA1946.2 12 bp overlap

EZH2 1 dataset

ChIP DND41 ENCSR000ASW.EZH2.DND41 364 bp overlap

Erg 2 datasets

Motif DE_48h DE_48h-Erg_MA0474.4 10 bp overlap

Motif DE_60h DE_60h-Erg_MA0474.4 10 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_36h DE_36h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 488 bp overlap

ChIP DE DE-FOXA2-2 545 bp overlap

FOXO1-PAX3 1 dataset

ChIP RH4_DMSO-6H GSE116344.FOXO1-PAX3.RH4_DMSO-6H 216 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_36h DE_36h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_36h DE_36h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_36h DE_36h-FOXO1FLI1_MA1956.2 13 bp overlap

GABPA 2 datasets

Motif DE_48h DE_48h-GABPA_MA0062.4 10 bp overlap

Motif DE_60h DE_60h-GABPA_MA0062.4 10 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 834 bp overlap

ChIP DE DE-GATA4-2 834 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 270 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 230 bp overlap

GATA5 2 datasets

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 834 bp overlap

ChIP DE DE-GATA6-2 834 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 834 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 834 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 834 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 834 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 834 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 834 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 834 bp overlap

GLI3 1 dataset

Motif DE_60h DE_60h-GLI3_MA1491.3 15 bp overlap

Gata3 2 datasets

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Gfi1B 2 datasets

Motif DE_48h DE_48h-Gfi1B_MA0483.2 10 bp overlap

Motif DE_60h DE_60h-Gfi1B_MA0483.2 10 bp overlap

HAND2 2 datasets

Motif DE_48h DE_48h-HAND2_MA1638.2 6 bp overlap

Motif DE_60h DE_60h-HAND2_MA1638.2 6 bp overlap

HNF4A 1 dataset

Motif DE_36h DE_36h-HNF4A_MA0114.5 9 bp overlap

HNF4G 1 dataset

Motif DE_36h DE_36h-HNF4G_MA0484.3 9 bp overlap

HOXB2::ELK1 2 datasets

Motif DE_48h DE_48h-HOXB2ELK1_MA1957.1 14 bp overlap

Motif DE_60h DE_60h-HOXB2ELK1_MA1957.1 14 bp overlap

IKZF1 1 dataset

Motif DE_36h DE_36h-IKZF1_MA1508.2 8 bp overlap

IRF4 2 datasets

ChIP NCI-H929 GSE142493.IRF4.NCI-H929 131 bp overlap

ChIP NCI-H929 GSE56857.IRF4.NCI-H929 131 bp overlap

MEIS1 1 dataset

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

MYOG 1 dataset

Motif DE_60h DE_60h-MYOG_MA0500.3 8 bp overlap

Mecom 2 datasets

Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap

Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap

Neurod2 1 dataset

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Olig2 1 dataset

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

RELA 1 dataset

ChIP aortic-endothelial-cell_IL1B_D4 GSE139377.RELA.aortic-endothelial-cell_IL1B_D4 177 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 792 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 834 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 344 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 289 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 275 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 429 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 469 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 256 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 458 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 427 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 540 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 291 bp overlap

TAL1 1 dataset

ChIP CD34 GSE52924.TAL1.CD34 93 bp overlap

TCF4 1 dataset

ChIP GEN2-2 GSE76147.TCF4.GEN2-2 292 bp overlap

TRPS1 2 datasets

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Tcf12 1 dataset

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

ZBTB11 2 datasets

Motif DE_48h DE_48h-ZBTB11_MA2329.1 9 bp overlap

Motif DE_60h DE_60h-ZBTB11_MA2329.1 9 bp overlap

ZNF175 1 dataset

Motif DE_48h DE_48h-ZNF175_MA2332.1 9 bp overlap

ZNF214 1 dataset

Motif DE_36h DE_36h-ZNF214_MA1975.2 13 bp overlap

ZNF449 3 datasets

ChIP HEK293 ENCFF764ZIC 411 bp overlap

ChIP HEK293 ENCSR738SLS.ZNF449.HEK293 340 bp overlap

ChIP HEK293 GSE76494.ZNF449.HEK293 132 bp overlap

ZNF707 2 datasets

Motif DE_48h DE_48h-ZNF707_MA1715.1 15 bp overlap

Motif DE_60h DE_60h-ZNF707_MA1715.1 15 bp overlap

ZNF766 1 dataset

ChIP HEK293T GSE78099.ZNF766.HEK293T 175 bp overlap

Zbtb2 2 datasets

Motif DE_48h DE_48h-Zbtb2_MA2340.1 10 bp overlap

Motif DE_60h DE_60h-Zbtb2_MA2340.1 10 bp overlap