This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SNX18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:54,309,736–54,312,389 | 207.1 kb | Distal (>10kb) Multiome | 930 | |
| chr5:54,415,815–54,416,851 | 101.5 kb | Distal (>10kb) Multiome | 250 | |
| chr5:54,514,413–54,514,604 | 3.2 kb | Proximal (<10kb) | 63 | |
| chr5:54,517,047–54,518,918 | 38 bp | At TSS Multiome | 820 | |
| chr5:54,872,603–54,873,437 | 355.3 kb | Distal (>10kb) Multiome HiCAR | 57 | |
| chr5:54,883,331–54,884,585 | 366.0 kb | Distal (>10kb) Multiome HiCAR | 266 | |
| chr5:54,904,261–54,905,542 | 387.0 kb | Distal (>10kb) Multiome HiCAR | 132 |
Genomic view of the SNX18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.