ETV3
ETS variant transcription factor 3 | PE-1

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-4 Developmental clusters: GC6
Biological processes 21 terms
DEAD/H-box RNA helicase binding (GO:0017151)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription repressor complex (GO:0090571)cell differentiation (GO:0030154)cellular response to granulocyte macrophage colony-stimulating factor stimulus (GO:0097011)chromatin (GO:0000785)chromatin (GO:0000785)negative regulation of cell population proliferation (GO:0008285)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription repressor complex (GO:0017053)
Expression (TPM)
ETV3 — as a Regulated Gene

TFs regulating ETV3 0 TFs

Transcription factors with Perturb-seq knockdown data for ETV3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETV3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ETV3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETV3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:156,845,268–156,845,794 292.8 kb Distal (>10kb) Multiome 73
chr1:156,848,614–156,849,138 289.4 kb Distal (>10kb) Multiome 129
chr1:156,860,147–156,861,294 277.7 kb Distal (>10kb) Multiome 484
chr1:156,862,753–156,863,585 275.1 kb Distal (>10kb) Multiome 268
chr1:156,892,162–156,892,597 245.9 kb Distal (>10kb) Multiome 439
chr1:156,893,409–156,893,975 244.5 kb Distal (>10kb) Multiome 143
chr1:156,920,128–156,921,047 217.8 kb Distal (>10kb) Multiome 508
chr1:156,927,257–156,928,255 210.5 kb Distal (>10kb) Multiome 424
chr1:156,996,881–156,997,694 141.0 kb Distal (>10kb) Multiome 167
chr1:157,045,268–157,046,656 92.4 kb Distal (>10kb) Multiome 678
chr1:157,074,275–157,074,755 63.9 kb Distal (>10kb) Multiome 204
chr1:157,131,134–157,132,464 5.9 kb Proximal (<10kb) 193
chr1:157,135,609–157,135,935 2.4 kb Proximal (<10kb) 35
chr1:157,137,885–157,139,148 187 bp At TSS Multiome 882
chr1:157,155,672–157,156,657 17.8 kb Distal (>10kb) Multiome 435
chr1:157,162,009–157,162,557 23.8 kb Distal (>10kb) Multiome 87
chr1:157,163,342–157,163,961 25.4 kb Distal (>10kb) Multiome 272
chr1:157,310,515–157,311,882 173.0 kb Distal (>10kb) Multiome 209

Genome Browser

Genomic view of the ETV3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:156,835,268 – 157,321,882
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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