Enables peroxidase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPX8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPX8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPX8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:54,872,603–54,873,437 | 287.2 kb | Distal (>10kb) Multiome HiCAR | 57 | |
| chr5:54,883,331–54,884,585 | 276.4 kb | Distal (>10kb) Multiome | 266 | |
| chr5:54,904,261–54,905,542 | 255.4 kb | Distal (>10kb) Multiome HiCAR | 132 | |
| chr5:55,029,649–55,030,875 | 129.8 kb | Distal (>10kb) Multiome | 91 | |
| chr5:55,159,780–55,160,259 | at TSS | At TSS | 340 | |
| chr5:55,160,994–55,161,172 | 800 bp | At TSS | 170 | |
| chr5:55,172,818–55,174,056 | 13.2 kb | Distal (>10kb) Multiome | 485 | |
| chr5:55,176,186–55,176,916 | 16.4 kb | Distal (>10kb) Multiome | 520 | |
| chr5:55,220,318–55,221,200 | 60.5 kb | Distal (>10kb) Multiome | 183 | |
| chr5:55,226,323–55,227,998 | 66.5 kb | Distal (>10kb) Multiome | 708 | |
| chr5:55,232,241–55,234,359 | 73.5 kb | Distal (>10kb) Multiome | 615 | |
| chr5:55,307,204–55,308,263 | 147.6 kb | Distal (>10kb) Multiome | 873 | |
| chr5:55,406,222–55,406,887 | 246.3 kb | Distal (>10kb) Multiome | 40 |
Genomic view of the GPX8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.