chr5 : 21,164,444 – 21,165,287

843 bp 67 TFs 1 linked gene

This 843 bp open chromatin element is linked to GUSBP1 and is bound by 67 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
GUSBP1		294.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

67 transcription factors

BARX1 1 dataset

Motif DE_48h DE_48h-BARX1_MA0875.2 6 bp overlap

BCL6B 1 dataset

Motif DE_48h DE_48h-BCL6B_MA0731.1 17 bp overlap

BSX 1 dataset

Motif DE_48h DE_48h-BSX_MA0876.2 6 bp overlap

CRX 3 datasets

ChIP retina_Hu20 GSE137311.CRX.retina_Hu20 273 bp overlap

ChIP retina_Hu3 GSE137311.CRX.retina_Hu3 259 bp overlap

ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 309 bp overlap

DLX1 1 dataset

Motif DE_48h DE_48h-DLX1_MA0879.3 6 bp overlap

DLX6 1 dataset

Motif DE_48h DE_48h-DLX6_MA0882.2 6 bp overlap

Dlx2 1 dataset

Motif DE_48h DE_48h-Dlx2_MA0885.3 8 bp overlap

Dlx3 1 dataset

Motif DE_48h DE_48h-Dlx3_MA0880.2 6 bp overlap

Dlx4 1 dataset

Motif DE_48h DE_48h-Dlx4_MA0881.2 6 bp overlap

Dlx5 1 dataset

Motif DE_48h DE_48h-Dlx5_MA1476.3 8 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 257 bp overlap

ETV5::HOXA2 1 dataset

Motif DE_48h DE_48h-ETV5HOXA2_MA1948.2 12 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 371 bp overlap

ChIP DE DE-FOXA2-2 293 bp overlap

ChIP DE DE-FOXA2-2 256 bp overlap

GATA1::TAL1 1 dataset

Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 843 bp overlap

ChIP DE DE-GATA4-2 843 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 559 bp overlap

GATA5 1 dataset

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

GATA6 12 datasets

ChIP DE DE-GATA6-1 843 bp overlap

ChIP DE DE-GATA6-2 843 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 406 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 374 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 817 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 321 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 403 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 843 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 660 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 587 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 500 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 540 bp overlap

GBX2 1 dataset

Motif DE_48h DE_48h-GBX2_MA0890.2 6 bp overlap

HAND2 1 dataset

Motif DE_48h DE_48h-HAND2_MA1638.2 6 bp overlap

HESX1 1 dataset

Motif DE_48h DE_48h-HESX1_MA0894.2 6 bp overlap

HOXA6 1 dataset

Motif DE_48h DE_48h-HOXA6_MA1497.2 7 bp overlap

HOXA7 1 dataset

Motif DE_48h DE_48h-HOXA7_MA1498.3 6 bp overlap

HOXB6 1 dataset

Motif DE_48h DE_48h-HOXB6_MA1500.2 7 bp overlap

HOXB7 1 dataset

Motif DE_48h DE_48h-HOXB7_MA1501.2 7 bp overlap

HOXB8 1 dataset

Motif DE_48h DE_48h-HOXB8_MA1502.2 7 bp overlap

HOXD8 1 dataset

Motif DE_48h DE_48h-HOXD8_MA0910.3 7 bp overlap

HOXD9 1 dataset

Motif DE_48h DE_48h-HOXD9_MA0913.3 9 bp overlap

Hmx1 1 dataset

Motif DE_48h DE_48h-Hmx1_MA0896.2 9 bp overlap

Hmx2 1 dataset

Motif DE_48h DE_48h-Hmx2_MA0897.2 15 bp overlap

Hmx3 1 dataset

Motif DE_48h DE_48h-Hmx3_MA0898.2 9 bp overlap

JUN 1 dataset

ChIP DE_D1 S40-DE-d1-JUN-exp2 263 bp overlap

LBX2 1 dataset

Motif DE_48h DE_48h-LBX2_MA0699.2 6 bp overlap

LHX2 1 dataset

Motif DE_48h DE_48h-LHX2_MA0700.3 6 bp overlap

MEF2D 2 datasets

ChIP retina_Hu13 GSE137311.MEF2D.retina_Hu13 223 bp overlap

ChIP retina_Hu25 GSE137311.MEF2D.retina_Hu25 233 bp overlap

MEIS1 2 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA1639.2 9 bp overlap

MEIS2 1 dataset

Motif DE_48h DE_48h-MEIS2_MA1640.2 9 bp overlap

MSX1 1 dataset

Motif DE_48h DE_48h-MSX1_MA0666.3 6 bp overlap

MSX2 1 dataset

Motif DE_48h DE_48h-MSX2_MA0708.3 6 bp overlap

Msx3 1 dataset

Motif DE_48h DE_48h-Msx3_MA0709.2 6 bp overlap

NEUROD1 2 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 283 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 256 bp overlap

NEUROG2 1 dataset

Motif DE_48h DE_48h-NEUROG2_MA1642.2 7 bp overlap

NRL 1 dataset

ChIP retina_Hu13 GSE137311.NRL.retina_Hu13 220 bp overlap

Nobox 1 dataset

Motif DE_48h DE_48h-Nobox_MA0125.2 6 bp overlap

OTX2 1 dataset

ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 320 bp overlap

PBX1 1 dataset

Motif DE_48h DE_48h-PBX1_MA0070.2 9 bp overlap

PBX2 1 dataset

Motif DE_48h DE_48h-PBX2_MA1113.3 9 bp overlap

PHOX2A 1 dataset

Motif DE_48h DE_48h-PHOX2A_MA0713.1 11 bp overlap

Ptf1A 1 dataset

Motif DE_48h DE_48h-Ptf1A_MA1618.2 9 bp overlap

RAX 1 dataset

Motif DE_48h DE_48h-RAX_MA0718.2 6 bp overlap

RBPJ 1 dataset

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

SMAD2 2 datasets

Motif DE_48h DE_48h-SMAD2_MA1964.2 6 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 213 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 643 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 639 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 496 bp overlap

SMAD2_3 6 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 444 bp overlap

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 271 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 843 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 839 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 822 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 843 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 186 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 168 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 766 bp overlap

Stat5a 1 dataset

Motif DE_48h DE_48h-Stat5a_MA1624.2 9 bp overlap

Stat5a::Stat5b 1 dataset

Motif DE_48h DE_48h-Stat5aStat5b_MA0519.2 9 bp overlap

Stat5b 1 dataset

Motif DE_48h DE_48h-Stat5b_MA1625.2 9 bp overlap

Stat6 1 dataset

Motif DE_48h DE_48h-Stat6_MA0520.2 10 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

TWIST1 1 dataset

Motif DE_48h DE_48h-TWIST1_MA1123.3 8 bp overlap

Thap11 1 dataset

Motif DE_48h DE_48h-Thap11_MA1573.2 14 bp overlap

Yy1 1 dataset

Motif DE_48h DE_48h-Yy1_MA0095.4 8 bp overlap

ZBTB18 1 dataset

Motif DE_48h DE_48h-ZBTB18_MA0698.2 11 bp overlap

ZNF136 1 dataset

Motif DE_48h DE_48h-ZNF136_MA1588.1 15 bp overlap

ZNF143 1 dataset

Motif DE_48h DE_48h-ZNF143_MA0088.2 16 bp overlap