chr8 : 280,251 – 280,793

542 bp 53 TFs 1 linked gene

This 542 bp open chromatin element is linked to ENSG00000288985 and is bound by 53 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000288985		5.9 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

53 transcription factors

CTCFL 1 dataset

Motif DE_60h DE_60h-CTCFL_MA1102.3 8 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF274GAT 178 bp overlap

ChIP BLaER1 ENCFF335XTP 119 bp overlap

Crx 1 dataset

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

DPRX 2 datasets

Motif DE_60h DE_60h-DPRX_MA1480.2 9 bp overlap

Motif DE_72h DE_72h-DPRX_MA1480.2 9 bp overlap

ETV2::HOXB13 1 dataset

Motif DE_60h DE_60h-ETV2HOXB13_MA1943.2 13 bp overlap

ETV5::FIGLA 1 dataset

Motif DE_60h DE_60h-ETV5FIGLA_MA1945.2 14 bp overlap

EZH2 3 datasets

ChIP A-1847_CARM1-KO GSE95643.EZH2.A-1847_CARM1-KO 382 bp overlap

ChIP THP-1 GSE135024.EZH2.THP-1 207 bp overlap

ChIP THP-1 GSE135024.EZH2.THP-1 209 bp overlap

EZH2_phosphoT487 1 dataset

ChIP PC-9 ENCSR702GMW.EZH2_phosphoT487.PC-9 234 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 409 bp overlap

ChIP DE DE-FOXA2-2 404 bp overlap

GATA1::TAL1 3 datasets

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 478 bp overlap

ChIP DE DE-GATA4-2 479 bp overlap

GATA6 6 datasets

ChIP DE DE-GATA6-1 470 bp overlap

ChIP DE DE-GATA6-2 464 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 385 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 274 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 438 bp overlap

ChIP foregut GSE117136.GATA6.foregut 261 bp overlap

GLIS2 1 dataset

Motif DE_60h DE_60h-GLIS2_MA0736.1 14 bp overlap

GSC 1 dataset

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

GSC2 1 dataset

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

HNF4A 1 dataset

Motif DE_60h DE_60h-HNF4A_MA0114.5 9 bp overlap

HNF4G 1 dataset

Motif DE_60h DE_60h-HNF4G_MA0484.3 9 bp overlap

KDM4A 1 dataset

ChIP WA01 ENCSR000AVC.KDM4A.WA01 161 bp overlap

KLF13 1 dataset

Motif DE_60h DE_60h-KLF13_MA0657.2 17 bp overlap

KMT2A 1 dataset

ChIP MOLM-13_VTP-d3-180110 GSE127507.KMT2A.MOLM-13_VTP-d3-180110 73 bp overlap

MEIS1 2 datasets

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MYB 1 dataset

Motif DE_60h DE_60h-MYB_MA0100.4 6 bp overlap

MZF1 1 dataset

Motif DE_60h DE_60h-MZF1_MA0056.3 8 bp overlap

NFATC3 1 dataset

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

NFATC4 1 dataset

Motif DE_60h DE_60h-NFATC4_MA1525.3 9 bp overlap

Nfat5 1 dataset

Motif DE_60h DE_60h-Nfat5_MA0606.3 8 bp overlap

Nfatc1 1 dataset

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Nr1h3::Rxra 1 dataset

Motif DE_60h DE_60h-Nr1h3Rxra_MA0494.2 16 bp overlap

Nr2e1 1 dataset

Motif DE_60h DE_60h-Nr2e1_MA0676.1 9 bp overlap

OTX1 1 dataset

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

OTX2 1 dataset

Motif DE_60h DE_60h-OTX2_MA0712.3 7 bp overlap

PITX1 1 dataset

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap

PITX3 1 dataset

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

PRDM1 1 dataset

Motif DE_60h DE_60h-PRDM1_MA0508.4 7 bp overlap

Plagl1 1 dataset

Motif DE_60h DE_60h-Plagl1_MA1615.2 8 bp overlap

Pou5f1::Sox2 2 datasets

Motif DE_60h DE_60h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_72h DE_72h-Pou5f1Sox2_MA0142.1 15 bp overlap

Pparg::Rxra 1 dataset

Motif DE_60h DE_60h-PpargRxra_MA0065.3 13 bp overlap

Prdm5 2 datasets

Motif DE_60h DE_60h-Prdm5_MA1999.2 11 bp overlap

Motif DE_72h DE_72h-Prdm5_MA1999.2 11 bp overlap

RHOXF1 1 dataset

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 319 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 344 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 429 bp overlap

SP5 1 dataset

Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

TBX5 1 dataset

Motif DE_60h DE_60h-TBX5_MA0807.1 8 bp overlap

Yy1 1 dataset

Motif DE_60h DE_60h-Yy1_MA0095.4 8 bp overlap

ZFP14 1 dataset

Motif DE_60h DE_60h-ZFP14_MA1972.1 15 bp overlap

ZNF257 2 datasets

Motif DE_60h DE_60h-ZNF257_MA1710.2 10 bp overlap

ZNF331 1 dataset

Motif DE_60h DE_60h-ZNF331_MA1726.2 10 bp overlap

ZNF416 2 datasets

Motif DE_60h DE_60h-ZNF416_MA1979.2 10 bp overlap

Motif DE_72h DE_72h-ZNF416_MA1979.2 10 bp overlap

ZNF530 1 dataset

Motif DE_60h DE_60h-ZNF530_MA1981.2 14 bp overlap

ZNF75A 2 datasets

Motif DE_60h DE_60h-ZNF75A_MA2097.1 12 bp overlap

Motif DE_72h DE_72h-ZNF75A_MA2097.1 12 bp overlap