chr12 : 70,617,419 – 70,617,870

451 bp 54 TFs 1 linked gene

This 451 bp open chromatin element is linked to PTPRB and is bound by 54 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
PTPRB		7.6 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

54 transcription factors

CHD7 1 dataset

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 451 bp overlap

Ddit3::Cebpa 1 dataset

Motif DE_12h DE_12h-Ddit3Cebpa_MA0019.2 10 bp overlap

EHF 1 dataset

Motif DE_12h DE_12h-EHF_MA0598.4 9 bp overlap

ELF3 1 dataset

Motif DE_12h DE_12h-ELF3_MA0640.3 9 bp overlap

ETV2::HOXB13 1 dataset

Motif DE_12h DE_12h-ETV2HOXB13_MA1943.2 13 bp overlap

ETV7 1 dataset

Motif DE_12h DE_12h-ETV7_MA1708.2 9 bp overlap

GATA1::TAL1 1 dataset

Motif DE_12h DE_12h-GATA1TAL1_MA0140.3 17 bp overlap

GATA6 5 datasets

ChIP DE_D1 S09-DE-d1-GATA6-exp1 271 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 367 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 373 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 396 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 385 bp overlap

GLIS2 1 dataset

Motif DE_12h DE_12h-GLIS2_MA0736.1 14 bp overlap

HDAC2 2 datasets

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 189 bp overlap

HMGB2 1 dataset

ChIP HUVEC-C GSE98245.HMGB2.HUVEC-C 305 bp overlap

Hand1 1 dataset

Motif DE_12h DE_12h-Hand1_MA2123.1 9 bp overlap

Hnf1A 1 dataset

Motif DE_12h DE_12h-Hnf1A_MA1991.2 10 bp overlap

INSM1 1 dataset

Motif DE_12h DE_12h-INSM1_MA0155.1 12 bp overlap

IRF3 1 dataset

Motif DE_12h DE_12h-IRF3_MA1418.2 17 bp overlap

JUN 1 dataset

ChIP HAEC_TNFa_4h GSE89970.JUN.HAEC_TNFa_4h 134 bp overlap

KLF4 2 datasets

ChIP BJ_INDUCED GSE36570.KLF4.BJ_INDUCED 200 bp overlap

Motif DE_12h DE_12h-KLF4_MA0039.5 8 bp overlap

MAFK 1 dataset

ChIP HepG2 ENCFF743ZOF 104 bp overlap

NANOG 2 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 374 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 163 bp overlap

NIPBL 1 dataset

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 293 bp overlap

POU5F1 2 datasets

ChIP BJ_INDUCED GSE36570.POU5F1.BJ_INDUCED 203 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 270 bp overlap

SIX2 3 datasets

ChIP HEK GSE73865.SIX2.HEK 167 bp overlap

ChIP kidney_fetal_16w GSE75948.SIX2.kidney_fetal_16w 120 bp overlap

ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 145 bp overlap

SMAD2 2 datasets

Motif DE_12h DE_12h-SMAD2_MA1964.2 6 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 409 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 270 bp overlap

SMARCA4 2 datasets

ChIP hiPSC GSE124903.SMARCA4.hiPSC 447 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 446 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 451 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 257 bp overlap

SMARCC1 1 dataset

ChIP hiPSC GSE124903.SMARCC1.hiPSC 451 bp overlap

SOX13 1 dataset

Motif DE_12h DE_12h-SOX13_MA1120.2 7 bp overlap

SOX2 2 datasets

Motif DE_12h DE_12h-SOX2_MA0143.5 7 bp overlap

ChIP HNSC GSE69479.SOX2.HNSC 381 bp overlap

SP1 1 dataset

ChIP WA01 ENCSR000BIR.SP1.WA01 171 bp overlap

SPIB 1 dataset

Motif DE_12h DE_12h-SPIB_MA0081.3 13 bp overlap

SPIC 1 dataset

Motif DE_12h DE_12h-SPIC_MA0687.2 13 bp overlap

Sox17 1 dataset

Motif DE_12h DE_12h-Sox17_MA0078.3 10 bp overlap

Sox3 1 dataset

Motif DE_12h DE_12h-Sox3_MA0514.3 7 bp overlap

Stat2 1 dataset

Motif DE_12h DE_12h-Stat2_MA1623.2 10 bp overlap

T 1 dataset

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 270 bp overlap

TBX19 2 datasets

Motif DE_12h DE_12h-TBX19_MA0804.2 17 bp overlap

TBXT 1 dataset

Motif DE_12h DE_12h-TBXT_MA0009.2 16 bp overlap

ZBTB26 1 dataset

Motif DE_12h DE_12h-ZBTB26_MA1579.2 8 bp overlap

ZIM3 1 dataset

Motif DE_12h DE_12h-ZIM3_MA1709.2 11 bp overlap

ZKSCAN3 1 dataset

Motif DE_12h DE_12h-ZKSCAN3_MA1973.2 14 bp overlap

ZNF213 1 dataset

Motif DE_12h DE_12h-ZNF213_MA2121.1 12 bp overlap

ZNF281 1 dataset

Motif DE_12h DE_12h-ZNF281_MA1630.3 10 bp overlap

ZNF316 1 dataset

ChIP K562 ENCFF838QCD 198 bp overlap

ZNF416 1 dataset

Motif DE_12h DE_12h-ZNF416_MA1979.2 10 bp overlap

ZNF462 1 dataset

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 228 bp overlap

ZNF485 1 dataset

ChIP HEK293T GSE78099.ZNF485.HEK293T 78 bp overlap

ZNF547 2 datasets

Motif DE_12h DE_12h-ZNF547_MA2334.1 13 bp overlap

ZNF684 1 dataset

Motif DE_12h DE_12h-ZNF684_MA1600.2 14 bp overlap

ZNF707 1 dataset

Motif DE_12h DE_12h-ZNF707_MA1715.1 15 bp overlap

ZNF85 1 dataset

Motif DE_12h DE_12h-ZNF85_MA1720.2 12 bp overlap

ZSCAN4 1 dataset

Motif DE_12h DE_12h-ZSCAN4_MA1155.1 15 bp overlap

Zfp809 1 dataset

Motif DE_12h DE_12h-Zfp809_MA2125.1 9 bp overlap

Zfx 1 dataset

Motif DE_12h DE_12h-Zfx_MA0146.3 10 bp overlap