chr21:44,283,183–44,283,881

chr21 : 44,283,183 – 44,283,881

698 bp 19 TFs 12 linked genes

This 698 bp open chromatin element is linked to 12 target genes and is bound by 19 transcription factors.

Linked Genes

12 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PFKL		16.6 kb	Distal	Multiome
ICOSLG		42.5 kb	Distal	Multiome
ENSG00000184441		47.8 kb	Distal	Multiome
CFAP410		55.9 kb	Distal	Multiome
TRPM2		70.2 kb	Distal	Multiome
GATD3		146.6 kb	Distal	Multiome
LRRC3		172.0 kb	Distal	Multiome
PWP2		176.1 kb	Distal	Multiome
LINC02575		202.0 kb	Distal	Multiome
TSPEAR-AS1		227.2 kb	Distal	Multiome
TSPEAR-AS2		233.8 kb	Distal	Multiome
TRAPPC10		271.1 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

19 transcription factors

BRD4 2 datasets

ChIP retina_AB1-FW20 GSE86981.BRD4.retina_AB1-FW20 94 bp overlap

ChIP retina_AB1-FW23 GSE86981.BRD4.retina_AB1-FW23 113 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 251 bp overlap

EZH2 2 datasets

ChIP SF8628 GSE94834.EZH2.SF8628 136 bp overlap

ChIP neural progenitor cell ENCFF018MKA 293 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 698 bp overlap

ChIP DE DE-FOXA2-2 698 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 597 bp overlap

ChIP DE DE-GATA4-2 677 bp overlap

GATA6 3 datasets

ChIP DE DE-GATA6-1 698 bp overlap

ChIP DE DE-GATA6-2 698 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 425 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 553 bp overlap

KLF1 2 datasets

ChIP HEK293 ENCFF159QSW 437 bp overlap

ChIP HEK293 ENCFF159QSW 270 bp overlap

KLF17 2 datasets

ChIP HEK293 ENCFF658MHR 238 bp overlap

ChIP HEK293 ENCFF658MHR 280 bp overlap

ChIP HEK293 ENCSR707BNG.MYNN.HEK293 108 bp overlap

POU5F1 2 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 445 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 183 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 411 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 315 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 258 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 366 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 564 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 425 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 625 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 698 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 342 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 622 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 139 bp overlap

ZNF592 1 dataset

ChIP GM12878 ENCFF818ABS 285 bp overlap

ZNF687 1 dataset

ChIP GM12878 ENCFF233SGE 416 bp overlap