Enables identical protein binding activity and receptor ligand activity. Involved in T follicular helper cell differentiation. Located in intracellular membrane-bounded organelle. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ICOSLG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ICOSLG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ICOSLG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:44,011,848–44,013,192 | 228.4 kb | Distal (>10kb) Multiome | 873 | |
| chr21:44,283,183–44,283,881 | 42.5 kb | Distal (>10kb) Multiome | 19 | |
| chr21:44,299,485–44,300,902 | 59.0 kb | Distal (>10kb) Multiome | 730 | |
| chr21:44,338,994–44,339,895 | 98.3 kb | Distal (>10kb) Multiome | 904 | |
| chr21:44,341,372–44,342,456 | 101.0 kb | Distal (>10kb) Multiome | 87 | |
| chr21:44,454,821–44,456,545 | 214.4 kb | Distal (>10kb) Multiome | 481 | |
| chr21:44,510,378–44,510,951 | 269.8 kb | Distal (>10kb) Multiome | 473 |
Genomic view of the ICOSLG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.