Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PWP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PWP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PWP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:43,775,786–43,776,893 | 330.9 kb | Distal (>10kb) Multiome HiCAR | 782 | |
| chr21:43,864,215–43,864,709 | 243.0 kb | Distal (>10kb) Multiome | 538 | |
| chr21:43,865,135–43,865,798 | 241.9 kb | Distal (>10kb) Multiome | 333 | |
| chr21:43,883,997–43,884,476 | 223.1 kb | Distal (>10kb) Multiome HiCAR | 418 | |
| chr21:43,921,393–43,922,764 | 185.4 kb | Distal (>10kb) Multiome | 622 | |
| chr21:44,011,848–44,013,192 | 94.8 kb | Distal (>10kb) Multiome | 873 | |
| chr21:44,283,183–44,283,881 | 176.1 kb | Distal (>10kb) Multiome | 19 | |
| chr21:44,299,485–44,300,902 | 192.6 kb | Distal (>10kb) Multiome | 730 | |
| chr21:44,338,994–44,339,895 | 231.8 kb | Distal (>10kb) Multiome | 904 | |
| chr21:44,341,372–44,342,456 | 234.6 kb | Distal (>10kb) Multiome | 87 |
Genomic view of the PWP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.