The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRAPPC10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAPPC10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAPPC10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:43,718,478–43,719,766 | 293.2 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,728,503–43,729,213 | 283.5 kb | Distal (>10kb) Multiome | 905 | |
| chr21:43,740,577–43,741,104 | 271.4 kb | Distal (>10kb) Multiome | 198 | |
| chr21:43,775,786–43,776,893 | 235.9 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,788,879–43,790,067 | 222.9 kb | Distal (>10kb) Multiome | 930 | |
| chr21:43,864,215–43,864,709 | 148.0 kb | Distal (>10kb) Multiome | 538 | |
| chr21:43,865,135–43,865,798 | 146.8 kb | Distal (>10kb) Multiome | 333 | |
| chr21:43,883,997–43,884,476 | 128.0 kb | Distal (>10kb) Multiome | 418 | |
| chr21:43,921,393–43,922,764 | 90.3 kb | Distal (>10kb) Multiome | 622 | |
| chr21:44,011,848–44,013,192 | 261 bp | At TSS Multiome | 873 | |
| chr21:44,283,183–44,283,881 | 271.1 kb | Distal (>10kb) Multiome | 19 | |
| chr21:44,299,485–44,300,902 | 287.6 kb | Distal (>10kb) Multiome | 730 |
Genomic view of the TRAPPC10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.