Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:44,283,183–44,283,881 | 172.0 kb | Distal (>10kb) Multiome | 19 | |
| chr21:44,299,485–44,300,902 | 155.5 kb | Distal (>10kb) Multiome | 730 | |
| chr21:44,338,994–44,339,895 | 116.3 kb | Distal (>10kb) Multiome HiCAR | 904 | |
| chr21:44,341,372–44,342,456 | 113.5 kb | Distal (>10kb) Multiome HiCAR | 87 | |
| chr21:44,454,821–44,456,545 | 188 bp | At TSS Multiome | 481 | |
| chr21:44,510,378–44,510,951 | 55.2 kb | Distal (>10kb) Multiome | 473 | |
| chr21:44,686,253–44,687,168 | 231.2 kb | Distal (>10kb) Multiome | 199 | |
| chr21:44,711,499–44,711,908 | 256.2 kb | Distal (>10kb) Multiome | 168 | |
| chr21:44,748,550–44,748,985 | 293.4 kb | Distal (>10kb) Multiome | 149 |
Genomic view of the LRRC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.