This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for MYO10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:16,465,184–16,466,419 | 276.0 kb | Distal (>10kb) Multiome | 953 | |
| chr5:16,575,212–16,575,703 | 166.5 kb | Distal (>10kb) Multiome | 124 | |
| chr5:16,616,186–16,617,558 | 125.0 kb | Distal (>10kb) Multiome | 428 | |
| chr5:16,733,759–16,734,037 | 7.9 kb | Proximal (<10kb) | 42 | |
| chr5:16,735,914–16,736,671 | 5.2 kb | Proximal (<10kb) | 507 | |
| chr5:16,737,662–16,738,837 | 3.6 kb | Proximal (<10kb) Multiome | 275 | |
| chr5:16,740,097–16,740,712 | 1.2 kb | Proximal (<10kb) | 52 | |
| chr5:16,741,012–16,741,168 | 741 bp | At TSS | 88 | |
| chr5:16,741,830–16,742,070 | at TSS | At TSS | 73 | |
| chr5:16,742,184–16,742,625 | 274 bp | At TSS | 99 | |
| chr5:16,900,382–16,901,591 | 158.7 kb | Distal (>10kb) Multiome | 195 | |
| chr5:16,935,234–16,937,118 | 194.5 kb | Distal (>10kb) Multiome | 661 |
Genomic view of the MYO10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.