Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ELOVL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELOVL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELOVL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:10,747,079–10,748,260 | 296.7 kb | Distal (>10kb) Multiome | 1006 | |
| chr6:10,837,383–10,838,947 | 205.8 kb | Distal (>10kb) Multiome | 773 | |
| chr6:10,886,419–10,887,541 | 157.3 kb | Distal (>10kb) Multiome | 615 | |
| chr6:11,007,370–11,008,733 | 36.3 kb | Distal (>10kb) Multiome | 412 | |
| chr6:11,043,323–11,045,047 | 148 bp | At TSS Multiome | 766 | |
| chr6:11,093,116–11,094,741 | 49.5 kb | Distal (>10kb) Multiome | 1088 | |
| chr6:11,229,067–11,229,994 | 185.1 kb | Distal (>10kb) Multiome | 412 | |
| chr6:11,231,826–11,233,562 | 188.4 kb | Distal (>10kb) Multiome | 894 |
Genomic view of the ELOVL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.