GC3

Gene Cluster 555 genes

Epithelial adhesion and immune response signatures

This 570-gene module includes key epithelial and immune regulators such as STAT3, CDH1, MMP9, and CD44, with enrichment in cell adhesion, immune response, and extracellular matrix processes. Knockdown of LRPPRC activates this module. Knockdown of FOXH1 represses this module.

Notable genes: STAT3 MMP9 CDH1 MMP2 CD44 HLA-A HMOX1 KDR Top TFs: FOXH1 SMAD4 SMAD3 CNBP MIXL1

555 member genes 38 TF regulators

TF Regulatory Network

Direction indicates the effect of TF knockdown on this gene cluster (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	padj	Bind	OR

Module Genes

Genes assigned to this temporal expression cluster (mfuzz).

Gene	Type	Publications