Transcription factors with Perturb-seq knockdown data for ENSG00000267383. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267383 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267383, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:20,038,984–20,039,716 | 199.0 kb | Distal (>10kb) Multiome | 495 | |
| chr19:20,051,726–20,052,860 | 186.2 kb | Distal (>10kb) Multiome | 402 | |
| chr19:20,066,768–20,067,242 | 171.4 kb | Distal (>10kb) Multiome | 8 | |
| chr19:20,067,957–20,069,262 | 169.5 kb | Distal (>10kb) Multiome | 17 | |
| chr19:20,077,737–20,078,423 | 160.5 kb | Distal (>10kb) Multiome | 212 | |
| chr19:20,082,410–20,083,233 | 155.6 kb | Distal (>10kb) Multiome | 155 | |
| chr19:20,166,957–20,167,632 | 71.2 kb | Distal (>10kb) Multiome | 222 | |
| chr19:20,233,114–20,233,593 | 4.8 kb | Proximal (<10kb) | 47 | |
| chr19:20,237,984–20,238,687 | 119 bp | At TSS Multiome | 188 | |
| chr19:20,238,818–20,239,246 | 376 bp | At TSS | 14 | |
| chr19:20,247,123–20,247,318 | 8.7 kb | Proximal (<10kb) | 25 | |
| chr19:20,248,201–20,248,701 | 9.8 kb | Proximal (<10kb) | 32 | |
| chr19:20,261,348–20,261,810 | 23.1 kb | Distal (>10kb) Multiome | 44 | |
| chr19:20,285,651–20,286,726 | 47.7 kb | Distal (>10kb) Multiome | 95 | |
| chr19:20,367,718–20,368,350 | 129.6 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr19:20,371,834–20,372,343 | 133.6 kb | Distal (>10kb) Multiome HiCAR | 96 | |
| chr19:20,424,664–20,425,178 | 186.5 kb | Distal (>10kb) Multiome | 133 | |
| chr19:20,776,028–20,776,925 | 537.8 kb | Distal (>10kb) Multiome HiCAR | 329 | |
| chr19:20,999,685–21,000,422 | 761.5 kb | Distal (>10kb) Multiome HiCAR | 234 | |
| chr19:21,020,242–21,021,293 | 782.2 kb | Distal (>10kb) Multiome HiCAR | 466 | |
| chr19:21,081,742–21,082,659 | 843.7 kb | Distal (>10kb) Multiome HiCAR | 412 | |
| chr19:21,141,765–21,142,544 | 903.6 kb | Distal (>10kb) Multiome HiCAR | 378 | |
| chr19:21,328,840–21,329,770 | 1090.9 kb | Distal (>10kb) Multiome HiCAR | 544 |
Genomic view of the ENSG00000267383 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.