The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for GULP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GULP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GULP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:188,032,198–188,034,514 | 259.2 kb | Distal (>10kb) Multiome HiCAR | 375 | |
| chr2:188,172,925–188,173,454 | 118.5 kb | Distal (>10kb) Multiome | 93 | |
| chr2:188,181,184–188,182,353 | 110.0 kb | Distal (>10kb) Multiome | 267 | |
| chr2:188,291,086–188,293,283 | 1.1 kb | Proximal (<10kb) Multiome | 756 | |
| chr2:188,293,584–188,294,501 | 1.9 kb | Proximal (<10kb) | 228 | |
| chr2:188,303,125–188,304,072 | 12.1 kb | Distal (>10kb) Multiome | 323 | |
| chr2:188,425,940–188,426,884 | 134.7 kb | Distal (>10kb) Multiome | 79 |
Genomic view of the GULP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.