This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for CADPS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CADPS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CADPS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:122,143,073–122,145,002 | 294.1 kb | Distal (>10kb) Multiome | 722 | |
| chr7:122,299,579–122,300,851 | 138.1 kb | Distal (>10kb) Multiome | 245 | |
| chr7:122,303,627–122,307,580 | 133.7 kb | Distal (>10kb) Multiome | 581 | |
| chr7:122,310,121–122,311,074 | 127.7 kb | Distal (>10kb) Multiome | 257 | |
| chr7:122,316,043–122,317,455 | 121.4 kb | Distal (>10kb) Multiome | 288 | |
| chr7:122,328,635–122,329,533 | 109.1 kb | Distal (>10kb) Multiome | 148 | |
| chr7:122,438,074–122,438,817 | 19 bp | At TSS Multiome | 200 | |
| chr7:122,679,074–122,680,087 | 241.1 kb | Distal (>10kb) Multiome | 403 | |
| chr7:122,885,481–122,887,941 | 448.3 kb | Distal (>10kb) Multiome | 789 |
Genomic view of the CADPS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.