This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARHGAP31. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP31 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP31, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:119,034,159–119,035,267 | 259.6 kb | Distal (>10kb) Multiome | 570 | |
| chr3:119,173,189–119,173,912 | 120.8 kb | Distal (>10kb) Multiome | 150 | |
| chr3:119,206,295–119,207,798 | 87.4 kb | Distal (>10kb) Multiome | 256 | |
| chr3:119,210,998–119,211,738 | 82.9 kb | Distal (>10kb) Multiome | 234 | |
| chr3:119,240,068–119,241,279 | 53.5 kb | Distal (>10kb) Multiome | 820 | |
| chr3:119,241,393–119,241,941 | 52.6 kb | Distal (>10kb) Multiome | 393 | |
| chr3:119,293,740–119,295,412 | 258 bp | At TSS Multiome | 540 | |
| chr3:119,322,394–119,324,118 | 28.6 kb | Distal (>10kb) Multiome | 824 | |
| chr3:119,349,421–119,349,961 | 55.2 kb | Distal (>10kb) Multiome | 181 | |
| chr3:119,350,134–119,350,644 | 55.9 kb | Distal (>10kb) Multiome HiCAR | 175 | |
| chr3:119,360,851–119,361,645 | 66.9 kb | Distal (>10kb) Multiome | 107 | |
| chr3:119,417,868–119,418,544 | 123.9 kb | Distal (>10kb) Multiome | 156 | |
| chr3:119,463,124–119,464,243 | 169.3 kb | Distal (>10kb) Multiome | 902 | |
| chr3:119,468,550–119,469,486 | 174.6 kb | Distal (>10kb) Multiome | 832 | |
| chr3:119,497,916–119,499,024 | 204.1 kb | Distal (>10kb) Multiome | 886 | |
| chr3:119,579,336–119,580,732 | 285.5 kb | Distal (>10kb) Multiome | 519 |
Genomic view of the ARHGAP31 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.