The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNFRSF10D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFRSF10D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFRSF10D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,864,299–22,865,847 | 299.0 kb | Distal (>10kb) Multiome | 507 | |
| chr8:22,916,000–22,916,628 | 247.8 kb | Distal (>10kb) Multiome | 199 | |
| chr8:22,998,974–23,000,300 | 164.5 kb | Distal (>10kb) Multiome | 597 | |
| chr8:23,019,069–23,020,109 | 144.6 kb | Distal (>10kb) Multiome | 452 | |
| chr8:23,049,698–23,050,409 | 114.0 kb | Distal (>10kb) Multiome | 277 | |
| chr8:23,068,457–23,069,444 | 95.0 kb | Distal (>10kb) Multiome | 856 | |
| chr8:23,083,702–23,084,469 | 79.7 kb | Distal (>10kb) Multiome | 538 | |
| chr8:23,162,920–23,164,386 | 127 bp | At TSS Multiome | 808 | |
| chr8:23,224,394–23,225,450 | 61.0 kb | Distal (>10kb) Multiome | 678 | |
| chr8:23,246,206–23,247,324 | 82.6 kb | Distal (>10kb) Multiome HiCAR | 941 | |
| chr8:23,287,908–23,288,715 | 124.1 kb | Distal (>10kb) Multiome | 853 | |
| chr8:23,403,157–23,405,109 | 240.1 kb | Distal (>10kb) Multiome | 425 | |
| chr8:23,451,094–23,451,922 | 287.5 kb | Distal (>10kb) Multiome | 182 | |
| chr8:23,457,148–23,458,219 | 293.6 kb | Distal (>10kb) Multiome | 736 |
Genomic view of the TNFRSF10D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.