Predicted to enable signaling receptor activity. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DCBLD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCBLD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCBLD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:117,264,496–117,266,315 | 217.0 kb | Distal (>10kb) Multiome | 442 | |
| chr6:117,270,051–117,271,235 | 212.0 kb | Distal (>10kb) Multiome | 235 | |
| chr6:117,478,279–117,479,098 | 3.5 kb | Proximal (<10kb) | 378 | |
| chr6:117,481,405–117,483,867 | 64 bp | At TSS Multiome | 1094 | |
| chr6:117,552,410–117,553,719 | 70.3 kb | Distal (>10kb) Multiome | 173 | |
| chr6:117,601,873–117,603,119 | 119.9 kb | Distal (>10kb) Multiome | 1002 | |
| chr6:117,674,767–117,676,565 | 192.8 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the DCBLD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.