This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for PDGFA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDGFA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDGFA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:321,971–322,829 | 197.5 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr7:332,380–333,313 | 187.0 kb | Distal (>10kb) Multiome | 649 | |
| chr7:514,963–515,154 | 5.1 kb | Proximal (<10kb) | 75 | |
| chr7:515,390–516,162 | 4.0 kb | Proximal (<10kb) Multiome | 84 | |
| chr7:516,552–517,550 | 2.7 kb | Proximal (<10kb) | 288 | |
| chr7:518,285–518,659 | 1.5 kb | Proximal (<10kb) | 143 | |
| chr7:518,879–521,101 | 266 bp | At TSS Multiome | 523 | |
| chr7:726,194–727,335 | 206.8 kb | Distal (>10kb) Multiome | 891 | |
| chr7:815,511–817,550 | 296.6 kb | Distal (>10kb) Multiome | 640 |
Genomic view of the PDGFA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.