This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for MARS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,214,315–57,214,722 | 273.5 kb | Distal (>10kb) Multiome | 318 | |
| chr12:57,215,826–57,217,972 | 271.4 kb | Distal (>10kb) Multiome | 525 | |
| chr12:57,219,094–57,219,803 | 268.6 kb | Distal (>10kb) Multiome | 71 | |
| chr12:57,224,526–57,225,152 | 263.0 kb | Distal (>10kb) Multiome | 267 | |
| chr12:57,225,987–57,227,617 | 261.0 kb | Distal (>10kb) Multiome | 236 | |
| chr12:57,229,358–57,230,407 | 258.3 kb | Distal (>10kb) Multiome | 739 | |
| chr12:57,237,805–57,241,749 | 248.9 kb | Distal (>10kb) Multiome | 846 | |
| chr12:57,242,371–57,244,402 | 244.3 kb | Distal (>10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 216.9 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 215.2 kb | Distal (>10kb) Multiome | 98 | |
| chr12:57,377,252–57,378,039 | 110.4 kb | Distal (>10kb) Multiome | 170 | |
| chr12:57,430,384–57,431,415 | 57.1 kb | Distal (>10kb) Multiome | 879 | |
| chr12:57,454,516–57,456,639 | 31.7 kb | Distal (>10kb) Multiome | 841 | |
| chr12:57,458,743–57,463,318 | 26.7 kb | Distal (>10kb) Multiome | 994 | |
| chr12:57,475,229–57,476,151 | 12.5 kb | Distal (>10kb) Multiome HiCAR | 194 | |
| chr12:57,487,577–57,488,336 | 117 bp | At TSS Multiome | 784 | |
| chr12:57,519,488–57,521,440 | 32.6 kb | Distal (>10kb) Multiome | 1029 | |
| chr12:57,521,541–57,523,658 | 34.6 kb | Distal (>10kb) Multiome | 960 | |
| chr12:57,546,771–57,547,419 | 59.2 kb | Distal (>10kb) Multiome | 623 | |
| chr12:57,549,654–57,550,343 | 62.0 kb | Distal (>10kb) Multiome | 366 | |
| chr12:57,583,383–57,583,948 | 95.5 kb | Distal (>10kb) Multiome | 353 | |
| chr12:57,590,813–57,591,877 | 103.1 kb | Distal (>10kb) Multiome | 738 | |
| chr12:57,604,466–57,605,404 | 116.8 kb | Distal (>10kb) Multiome | 337 | |
| chr12:57,609,052–57,609,957 | 121.3 kb | Distal (>10kb) Multiome | 83 | |
| chr12:57,610,841–57,611,876 | 123.4 kb | Distal (>10kb) Multiome | 558 | |
| chr12:57,621,603–57,622,199 | 133.8 kb | Distal (>10kb) Multiome | 446 | |
| chr12:57,631,837–57,633,369 | 145.1 kb | Distal (>10kb) Multiome | 706 | |
| chr12:57,693,486–57,694,647 | 205.9 kb | Distal (>10kb) Multiome | 757 | |
| chr12:57,726,079–57,726,879 | 238.2 kb | Distal (>10kb) Multiome | 597 | |
| chr12:57,738,612–57,739,176 | 251.0 kb | Distal (>10kb) Multiome | 201 | |
| chr12:57,744,434–57,745,735 | 256.9 kb | Distal (>10kb) Multiome | 822 | |
| chr12:57,751,806–57,753,147 | 264.4 kb | Distal (>10kb) Multiome | 1030 | |
| chr12:57,754,455–57,756,188 | 266.9 kb | Distal (>10kb) Multiome | 616 | |
| chr12:57,756,649–57,757,193 | 268.9 kb | Distal (>10kb) Multiome | 315 | |
| chr12:57,765,020–57,765,720 | 277.3 kb | Distal (>10kb) Multiome | 472 | |
| chr12:57,766,452–57,767,514 | 279.0 kb | Distal (>10kb) Multiome | 330 | |
| chr12:57,771,528–57,773,018 | 284.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:57,782,579–57,783,204 | 294.7 kb | Distal (>10kb) Multiome | 916 |
Genomic view of the MARS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.