Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Modules significantly affected by knockdown. ↑ Up = module upregulated upon KD; ↓ Down = module downregulated upon KD.
| Module | Dir | NES | #gRNA | padj | Bind | OR | padj (bind) |
|---|
| Submodule | Module | Dir | NES | #gRNA | Bind | OR | padj (bind) |
|---|
Genes likely regulated by ZNF787 through linked binding evidence in open chromatin. The chart ranks TF-linked genes by their mean Perturb-seq response to ZNF787 knockdown, with negative coefficients indicating downregulation and positive coefficients indicating upregulation upon knockdown.
Open chromatin elements (ATAC-seq) where ZNF787 has ChIP-seq or motif footprint binding evidence and which are linked to at least one target gene region.
| Element | Size | Linked genes |
|---|
Transcription factors with Perturb-seq knockdown data for ZNF787. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF787 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF787, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:56,120,040–56,122,160 | 197 bp | At TSS Multiome | 1006 | |
| chr19:56,140,231–56,141,860 | 19.7 kb | Distal (>10kb) Multiome | 744 | |
| chr19:56,217,208–56,217,951 | 96.3 kb | Distal (>10kb) Multiome | 116 | |
| chr19:56,314,052–56,315,623 | 193.8 kb | Distal (>10kb) Multiome | 844 | |
| chr19:56,346,962–56,347,557 | 226.0 kb | Distal (>10kb) Multiome | 97 | |
| chr19:56,367,790–56,368,666 | 247.0 kb | Distal (>10kb) Multiome | 609 | |
| chr19:56,393,166–56,393,951 | 272.3 kb | Distal (>10kb) Multiome | 653 | |
| chr19:56,403,714–56,404,765 | 282.9 kb | Distal (>10kb) Multiome | 745 |
Genomic view of the ZNF787 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.