The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for NBR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NBR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NBR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,964,237–42,964,843 | 206.0 kb | Distal (>10kb) Multiome | 655 | |
| chr17:42,979,966–42,981,044 | 190.0 kb | Distal (>10kb) Multiome | 843 | |
| chr17:42,997,598–42,998,917 | 172.2 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:43,021,026–43,022,568 | 148.1 kb | Distal (>10kb) Multiome | 973 | |
| chr17:43,024,255–43,025,752 | 145.5 kb | Distal (>10kb) Multiome | 811 | |
| chr17:43,124,981–43,125,702 | 45.0 kb | Distal (>10kb) Multiome | 837 | |
| chr17:43,169,744–43,171,576 | 657 bp | At TSS Multiome | 1018 | |
| chr17:43,211,494–43,212,392 | 41.5 kb | Distal (>10kb) Multiome | 586 | |
| chr17:43,359,784–43,361,254 | 190.6 kb | Distal (>10kb) Multiome | 981 | |
| chr17:43,367,132–43,369,458 | 198.7 kb | Distal (>10kb) Multiome | 1146 | |
| chr17:43,388,101–43,389,658 | 218.9 kb | Distal (>10kb) Multiome | 770 | |
| chr17:43,396,555–43,396,987 | 226.3 kb | Distal (>10kb) Multiome | 27 | |
| chr17:43,398,359–43,400,469 | 228.4 kb | Distal (>10kb) Multiome | 827 | |
| chr17:43,403,154–43,404,714 | 233.5 kb | Distal (>10kb) Multiome | 252 | |
| chr17:43,406,748–43,407,604 | 236.7 kb | Distal (>10kb) Multiome | 102 | |
| chr17:43,438,695–43,439,408 | 268.5 kb | Distal (>10kb) Multiome | 86 | |
| chr17:43,457,977–43,459,063 | 288.0 kb | Distal (>10kb) Multiome | 328 |
Genomic view of the NBR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.