Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TNFAIP8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFAIP8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFAIP8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:118,987,706–118,989,045 | 280.3 kb | Distal (>10kb) Multiome | 941 | |
| chr5:119,070,182–119,071,897 | 197.7 kb | Distal (>10kb) Multiome | 975 | |
| chr5:119,255,677–119,256,535 | 12.6 kb | Distal (>10kb) Multiome | 184 | |
| chr5:119,265,800–119,266,195 | 2.6 kb | Proximal (<10kb) | 5 | |
| chr5:119,267,854–119,269,617 | 102 bp | At TSS Multiome | 918 | |
| chr5:119,271,300–119,271,807 | 2.5 kb | Proximal (<10kb) | 63 | |
| chr5:119,274,397–119,274,761 | 5.6 kb | Proximal (<10kb) | 205 | |
| chr5:119,275,876–119,276,094 | 7.1 kb | Proximal (<10kb) | 90 | |
| chr5:119,316,153–119,316,863 | 47.7 kb | Distal (>10kb) Multiome | 112 | |
| chr5:119,354,971–119,356,548 | 87.1 kb | Distal (>10kb) Multiome | 521 | |
| chr5:119,409,419–119,410,763 | 141.5 kb | Distal (>10kb) Multiome | 149 | |
| chr5:119,452,092–119,453,354 | 183.9 kb | Distal (>10kb) Multiome | 894 | |
| chr5:119,470,201–119,470,844 | 201.8 kb | Distal (>10kb) Multiome | 179 | |
| chr5:119,480,236–119,481,736 | 212.2 kb | Distal (>10kb) Multiome | 177 |
Genomic view of the TNFAIP8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.