This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SGK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:66,512,582–66,513,139 | 262.3 kb | Distal (>10kb) Multiome | 239 | |
| chr8:66,612,352–66,614,219 | 161.8 kb | Distal (>10kb) Multiome | 862 | |
| chr8:66,666,261–66,667,884 | 107.8 kb | Distal (>10kb) Multiome | 889 | |
| chr8:66,712,294–66,713,281 | 62.5 kb | Distal (>10kb) Multiome | 648 | |
| chr8:66,774,026–66,775,860 | 18 bp | At TSS Multiome | 957 | |
| chr8:66,778,292–66,778,485 | 3.1 kb | Proximal (<10kb) | 19 | |
| chr8:66,870,495–66,871,236 | 95.6 kb | Distal (>10kb) Multiome | 352 | |
| chr8:66,924,535–66,926,136 | 150.4 kb | Distal (>10kb) Multiome | 998 | |
| chr8:66,961,090–66,963,532 | 187.5 kb | Distal (>10kb) Multiome | 438 | |
| chr8:67,028,419–67,029,071 | 253.4 kb | Distal (>10kb) Multiome | 488 | |
| chr8:67,061,734–67,062,754 | 287.1 kb | Distal (>10kb) Multiome | 733 | |
| chr8:67,063,914–67,065,235 | 289.2 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the SGK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.