Enables L-amino acid transmembrane transporter activity and secondary active transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in several cellular components, including apical plasma membrane; cytosol; and microvillus membrane. Part of amino acid transport complex. Implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Biomarker of esophagitis; gastrointestinal system cancer (multiple); malignant astrocytoma (multiple); and respiratory system cancer (multiple). [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SLC7A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:87,601,726–87,602,537 | 267.2 kb | Distal (>10kb) Multiome | 217 | |
| chr16:87,765,695–87,766,281 | 103.5 kb | Distal (>10kb) Multiome | 846 | |
| chr16:87,777,440–87,778,323 | 91.6 kb | Distal (>10kb) Multiome HiCAR | 751 | |
| chr16:87,778,885–87,779,577 | 90.2 kb | Distal (>10kb) Multiome HiCAR | 990 | |
| chr16:87,868,765–87,870,102 | 40 bp | At TSS Multiome | 674 | |
| chr16:87,870,439–87,871,185 | 1.4 kb | Proximal (<10kb) Multiome | 528 | |
| chr16:87,871,635–87,871,847 | 2.1 kb | Proximal (<10kb) | 434 | |
| chr16:87,872,576–87,872,847 | 3.1 kb | Proximal (<10kb) | 68 | |
| chr16:87,874,680–87,875,089 | 5.2 kb | Proximal (<10kb) | 94 | |
| chr16:87,950,629–87,952,113 | 81.7 kb | Distal (>10kb) Multiome | 1107 |
Genomic view of the SLC7A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.