Enables L-leucine binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to L-leucine; protein K63-linked ubiquitination; and regulation of signal transduction. Predicted to be located in cytosol. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:42,451,208–42,454,840 | 112.2 kb | Distal (>10kb) Multiome | 808 | |
| chr6:42,547,405–42,547,886 | 16.3 kb | Distal (>10kb) Multiome | 570 | |
| chr6:42,563,541–42,564,644 | 18 bp | At TSS Multiome | 1040 | |
| chr6:42,710,310–42,710,904 | 146.5 kb | Distal (>10kb) Multiome | 100 | |
| chr6:42,745,261–42,747,361 | 182.2 kb | Distal (>10kb) Multiome | 1101 | |
| chr6:42,770,933–42,771,516 | 207.2 kb | Distal (>10kb) Multiome | 283 | |
| chr6:42,782,323–42,783,894 | 218.9 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the UBR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.