This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for LRIG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRIG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRIG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,714,149–112,716,774 | 356.6 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr1:112,790,881–112,791,569 | 281.9 kb | Distal (>10kb) Multiome | 158 | |
| chr1:112,794,180–112,795,498 | 278.1 kb | Distal (>10kb) Multiome | 251 | |
| chr1:112,809,091–112,810,187 | 263.5 kb | Distal (>10kb) Multiome HiCAR | 445 | |
| chr1:112,817,716–112,818,473 | 255.1 kb | Distal (>10kb) Multiome | 249 | |
| chr1:112,819,120–112,820,730 | 253.8 kb | Distal (>10kb) Multiome | 456 | |
| chr1:112,825,474–112,826,954 | 247.3 kb | Distal (>10kb) Multiome HiCAR | 182 | |
| chr1:112,841,024–112,841,798 | 231.8 kb | Distal (>10kb) Multiome | 215 | |
| chr1:112,849,324–112,850,157 | 223.4 kb | Distal (>10kb) Multiome HiCAR | 352 | |
| chr1:112,955,281–112,957,849 | 116.9 kb | Distal (>10kb) Multiome | 1108 | |
| chr1:113,040,180–113,041,009 | 32.8 kb | Distal (>10kb) Multiome | 248 | |
| chr1:113,041,702–113,043,423 | 30.4 kb | Distal (>10kb) Multiome | 544 | |
| chr1:113,043,627–113,044,178 | 29.2 kb | Distal (>10kb) Multiome | 105 | |
| chr1:113,072,181–113,073,766 | 125 bp | At TSS Multiome | 975 | |
| chr1:113,140,616–113,141,422 | 67.8 kb | Distal (>10kb) Multiome | 413 | |
| chr1:113,217,521–113,218,452 | 144.8 kb | Distal (>10kb) Multiome | 479 | |
| chr1:113,223,494–113,224,107 | 150.6 kb | Distal (>10kb) Multiome | 75 | |
| chr1:113,234,064–113,234,645 | 161.2 kb | Distal (>10kb) Multiome | 67 | |
| chr1:113,252,166–113,252,950 | 179.2 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the LRIG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.