The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for APPBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APPBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APPBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:60,327,303–60,327,917 | 198.3 kb | Distal (>10kb) Multiome | 115 | |
| chr17:60,384,860–60,385,543 | 140.8 kb | Distal (>10kb) Multiome | 76 | |
| chr17:60,391,203–60,392,936 | 133.7 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:60,421,283–60,422,169 | 104.3 kb | Distal (>10kb) Multiome | 479 | |
| chr17:60,525,577–60,526,500 | 221 bp | At TSS Multiome | 955 | |
| chr17:60,579,473–60,580,626 | 54.0 kb | Distal (>10kb) Multiome | 205 | |
| chr17:60,599,336–60,601,434 | 74.2 kb | Distal (>10kb) Multiome | 1120 | |
| chr17:60,676,921–60,678,448 | 151.8 kb | Distal (>10kb) Multiome | 986 |
Genomic view of the APPBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.