This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SYNRG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYNRG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYNRG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:37,358,363–37,360,066 | 250.1 kb | Distal (>10kb) Multiome | 859 | |
| chr17:37,406,418–37,407,500 | 202.4 kb | Distal (>10kb) Multiome | 822 | |
| chr17:37,488,914–37,490,446 | 119.6 kb | Distal (>10kb) Multiome | 759 | |
| chr17:37,608,867–37,609,901 | 55 bp | At TSS Multiome | 930 | |
| chr17:37,643,162–37,643,681 | 34.1 kb | Distal (>10kb) Multiome | 540 | |
| chr17:37,709,949–37,710,763 | 101.1 kb | Distal (>10kb) Multiome | 375 | |
| chr17:37,725,144–37,726,036 | 116.1 kb | Distal (>10kb) Multiome | 148 | |
| chr17:37,743,503–37,745,720 | 135.8 kb | Distal (>10kb) Multiome | 528 |
Genomic view of the SYNRG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.