This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for ALG11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALG11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALG11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:51,795,081–51,795,749 | 216.9 kb | Distal (>10kb) Multiome | 50 | |
| chr13:51,803,129–51,804,466 | 208.4 kb | Distal (>10kb) Multiome | 844 | |
| chr13:51,997,545–51,998,310 | 14.3 kb | Distal (>10kb) Multiome | 461 | |
| chr13:52,011,124–52,012,698 | 207 bp | At TSS Multiome | 960 | |
| chr13:52,128,284–52,129,389 | 116.6 kb | Distal (>10kb) Multiome | 598 | |
| chr13:52,159,155–52,160,117 | 147.1 kb | Distal (>10kb) Multiome | 831 | |
| chr13:52,194,155–52,194,839 | 182.1 kb | Distal (>10kb) Multiome | 888 | |
| chr13:52,195,279–52,195,948 | 183.3 kb | Distal (>10kb) Multiome | 267 |
Genomic view of the ALG11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.