ANGEL2
angel homolog 2 | Ccr4d, FLJ12793, KIAA0759L

Enables mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Located in Cajal body and cytoplasm. Is active in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.27
Biological processes 24 terms
3'-UTR-mediated mRNA stabilization (GO:0070935)Cajal body (GO:0015030)RNA 2',3'-cyclic phosphatase activity (GO:0160272)RNA 2',3'-cyclic phosphatase activity (GO:0160272)RNA 2',3'-cyclic phosphatase activity (GO:0160272)RNA 2',3'-cyclic phosphatase activity (GO:0160272)RNA 2'-phosphatase activity (GO:0160273)RNA 2'-phosphatase activity (GO:0160273)catalytic activity (GO:0003824)cytoplasm (GO:0005737)hydrolase activity, acting on ester bonds (GO:0016788)mRNA 3'-UTR binding (GO:0003730)mRNA 3'-UTR binding (GO:0003730)magnesium ion binding (GO:0000287)mitochondrial mRNA 3'-end processing (GO:0090616)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)negative regulation of RNA splicing (GO:0033119)negative regulation of mitotic cell cycle (GO:0045930)negative regulation of tRNA processing (GO:2000236)nuclear-transcribed mRNA catabolic process, non-stop decay (GO:0070481)nucleus (GO:0005634)
Expression (TPM)
ANGEL2 — as a Regulated Gene

TFs regulating ANGEL2 0 TFs

Transcription factors with Perturb-seq knockdown data for ANGEL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANGEL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ANGEL2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANGEL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:212,791,461–212,792,424 223.6 kb Distal (>10kb) Multiome 1108
chr1:212,857,574–212,859,115 157.4 kb Distal (>10kb) Multiome 946
chr1:212,860,779–212,861,295 154.5 kb Distal (>10kb) Multiome 315
chr1:212,907,964–212,908,918 107.1 kb Distal (>10kb) Multiome 62
chr1:212,909,569–212,910,174 105.4 kb Distal (>10kb) Multiome 97
chr1:212,916,378–212,917,359 98.5 kb Distal (>10kb) Multiome 306
chr1:212,928,624–212,929,308 86.4 kb Distal (>10kb) Multiome 145
chr1:212,950,130–212,951,519 65.0 kb Distal (>10kb) Multiome 457
chr1:212,967,458–212,968,096 47.6 kb Distal (>10kb) Multiome 178
chr1:213,015,122–213,015,983 158 bp At TSS Multiome 888
chr1:213,050,888–213,051,797 35.8 kb Distal (>10kb) Multiome 880
chr1:213,066,260–213,067,034 51.2 kb Distal (>10kb) Multiome 70
chr1:213,231,902–213,232,438 216.6 kb Distal (>10kb) Multiome 196
chr1:213,260,264–213,261,320 245.4 kb Distal (>10kb) Multiome 165
chr1:214,316,395–214,317,010 1301.3 kb Distal (>10kb) Multiome HiCAR 226
chr1:214,317,130–214,317,628 1302.0 kb Distal (>10kb) Multiome HiCAR 145

Genome Browser

Genomic view of the ANGEL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:212,781,461 – 214,327,628
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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