ATG13

autophagy related 13 | KIAA0652

The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]

Member of: DE-10 DE-10.4

Biological processes 39 terms

Atg1/ULK1 kinase complex (GO:1990316)Atg1/ULK1 kinase complex (GO:1990316)Atg1/ULK1 kinase complex (GO:1990316)autophagosome (GO:0005776)autophagosome assembly (GO:0000045)autophagosome assembly (GO:0000045)autophagosome assembly (GO:0000045)autophagosome assembly (GO:0000045)autophagy (GO:0006914)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum membrane (GO:0005789)kinase activator activity (GO:0019209)macroautophagy (GO:0016236)mitochondrion (GO:0005739)mitophagy (GO:0000423)mitophagy (GO:0000423)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)phagophore assembly site (GO:0000407)phagophore assembly site (GO:0000407)phagophore assembly site (GO:0000407)phagophore assembly site (GO:0000407)phagophore assembly site membrane (GO:0034045)piecemeal microautophagy of the nucleus (GO:0034727)positive regulation of autophagy (GO:0010508)positive regulation of autophagy (GO:0010508)positive regulation of protein localization to mitochondrion (GO:1903749)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein kinase regulator activity (GO:0019887)protein localization to phagophore assembly site (GO:0034497)regulation of cell population proliferation (GO:0042127)regulation of protein lipidation (GO:1903059)response to mitochondrial depolarisation (GO:0098780)

Expression (TPM)

TFs regulating ATG13 0 TFs

Transcription factors with Perturb-seq knockdown data for ATG13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATG13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ATG13

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATG13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:46,338,698–46,339,679	278.3 kb	Distal (>10kb) Multiome	393
chr11:46,346,987–46,348,092	270.2 kb	Distal (>10kb) Multiome	586
chr11:46,352,002–46,352,557	265.2 kb	Distal (>10kb) Multiome	306
chr11:46,379,120–46,383,444	237.9 kb	Distal (>10kb) Multiome	930
chr11:46,388,459–46,390,750	228.7 kb	Distal (>10kb) Multiome	593
chr11:46,391,139–46,393,221	224.8 kb	Distal (>10kb) Multiome	965
chr11:46,407,311–46,408,466	209.7 kb	Distal (>10kb) Multiome	157
chr11:46,554,280–46,555,184	62.8 kb	Distal (>10kb) Multiome	531
chr11:46,593,562–46,594,345	23.6 kb	Distal (>10kb) Multiome	845
chr11:46,616,855–46,618,064	246 bp	At TSS Multiome	823
chr11:46,664,502–46,665,016	47.2 kb	Distal (>10kb) Multiome	126
chr11:46,674,791–46,675,556	57.6 kb	Distal (>10kb) Multiome	308
chr11:46,700,262–46,701,275	83.2 kb	Distal (>10kb) Multiome	997
chr11:46,826,562–46,827,053	209.3 kb	Distal (>10kb) Multiome	529
chr11:46,845,538–46,846,680	228.7 kb	Distal (>10kb) Multiome	879
chr11:46,912,540–46,913,271	295.3 kb	Distal (>10kb) Multiome	252

Genome Browser

Genomic view of the ATG13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.