This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MTMR9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTMR9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTMR9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:10,928,278–10,929,029 | 356.2 kb | Distal (>10kb) Multiome HiCAR | 503 | |
| chr8:11,015,417–11,017,389 | 268.2 kb | Distal (>10kb) Multiome HiCAR | 681 | |
| chr8:11,047,960–11,048,530 | 236.6 kb | Distal (>10kb) Multiome HiCAR | 130 | |
| chr8:11,059,056–11,059,876 | 225.3 kb | Distal (>10kb) Multiome | 226 | |
| chr8:11,200,019–11,201,991 | 83.3 kb | Distal (>10kb) Multiome | 601 | |
| chr8:11,246,809–11,247,816 | 37.5 kb | Distal (>10kb) Multiome | 167 | |
| chr8:11,283,848–11,285,272 | 285 bp | At TSS Multiome | 985 | |
| chr8:11,288,724–11,289,361 | 3.9 kb | Proximal (<10kb) | 70 | |
| chr8:11,346,754–11,348,253 | 62.8 kb | Distal (>10kb) Multiome | 547 | |
| chr8:11,439,886–11,440,775 | 155.5 kb | Distal (>10kb) Multiome | 160 | |
| chr8:11,466,250–11,468,072 | 182.9 kb | Distal (>10kb) Multiome | 594 | |
| chr8:11,563,746–11,564,943 | 279.9 kb | Distal (>10kb) Multiome | 644 |
Genomic view of the MTMR9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.