Enables cadherin binding activity involved in cell-cell adhesion. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in adherens junction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMOD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMOD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMOD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:51,621,891–51,623,295 | 206.8 kb | Distal (>10kb) Multiome | 786 | |
| chr15:51,681,155–51,681,883 | 148.1 kb | Distal (>10kb) Multiome | 662 | |
| chr15:51,726,326–51,726,848 | 103.1 kb | Distal (>10kb) Multiome | 334 | |
| chr15:51,736,980–51,738,047 | 92.1 kb | Distal (>10kb) Multiome | 521 | |
| chr15:51,751,070–51,752,267 | 78.1 kb | Distal (>10kb) Multiome | 433 | |
| chr15:51,829,316–51,830,426 | 126 bp | At TSS Multiome | 787 | |
| chr15:51,971,175–51,972,397 | 142.2 kb | Distal (>10kb) Multiome | 887 | |
| chr15:52,008,542–52,009,373 | 179.3 kb | Distal (>10kb) Multiome | 499 | |
| chr15:52,018,740–52,020,253 | 189.6 kb | Distal (>10kb) Multiome | 1045 | |
| chr15:52,111,990–52,112,768 | 282.8 kb | Distal (>10kb) Multiome | 189 |
Genomic view of the TMOD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.