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DE-1.12

Submodule 25 genes

Proteasome and mitochondrial ATP synthesis complex

This 25-gene module includes PPP1CA, CSNK2B, PHB2, TMBIM6, and ADRM1, with strong enrichment for proteasome complex, endopeptidase complex, and peptidase complex components, alongside pathways for oxidative phosphorylation and proton motive force-driven ATP synthesis. No transcription factor knockdown data are available for this module.

Key terms: oxidative phosphorylation proton motive force-driven mitochondrial ATP synthesis proton motive force-driven ATP synthesis ATP biosynthetic process Notable genes: PPP1CA CSNK2B PHB2 TMBIM6 ADRM1 ATP5IF1 TALDO1 PSMA3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (25)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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