ADRM1
ADRM1 26S proteasome ubiquitin receptor | ARM1, GP110, PSMD16, Rpn13

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Member of: DE-1 DE-1.12
Biological processes 24 terms
cellular response to type I interferon (GO:0071357)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endopeptidase activator activity (GO:0061133)endopeptidase activator activity (GO:0061133)molecular function inhibitor activity (GO:0140678)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)protease binding (GO:0002020)proteasomal protein catabolic process (GO:0010498)proteasome assembly (GO:0043248)proteasome binding (GO:0070628)proteasome binding (GO:0070628)proteasome complex (GO:0000502)proteasome regulatory particle, lid subcomplex (GO:0008541)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)regulation of proteasomal protein catabolic process (GO:0061136)response to oxidative stress (GO:0006979)synaptic vesicle (GO:0008021)transcription elongation by RNA polymerase II (GO:0006368)
Expression (TPM)
ADRM1 — as a Regulated Gene

TFs regulating ADRM1 0 TFs

Transcription factors with Perturb-seq knockdown data for ADRM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADRM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ADRM1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADRM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr20:62,065,357–62,067,442 236.9 kb Distal (>10kb) Multiome 841
chr20:62,121,331–62,123,419 180.8 kb Distal (>10kb) Multiome 961
chr20:62,142,789–62,144,593 159.5 kb Distal (>10kb) Multiome 841
chr20:62,182,546–62,183,326 120.0 kb Distal (>10kb) Multiome 1075
chr20:62,219,369–62,220,936 82.7 kb Distal (>10kb) Multiome 599
chr20:62,237,918–62,239,210 64.6 kb Distal (>10kb) Multiome 794
chr20:62,301,857–62,303,576 824 bp At TSS Multiome 1110
chr20:62,365,805–62,369,404 66.0 kb Distal (>10kb) Multiome 960
chr20:62,386,553–62,387,309 84.0 kb Distal (>10kb) Multiome 885
chr20:62,406,793–62,407,817 104.4 kb Distal (>10kb) Multiome 935
chr20:62,475,060–62,476,807 173.1 kb Distal (>10kb) Multiome 378
chr20:62,487,549–62,488,006 184.7 kb Distal (>10kb) Multiome 316

Genome Browser

Genomic view of the ADRM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr20:62,055,357 – 62,498,006
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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