Enables several functions, including ATPase binding activity; angiostatin binding activity; and mitochondrial proton-transporting ATP synthase complex binding activity. Involved in several processes, including mitochondrial depolarization; negative regulation of endothelial cell proliferation; and positive regulation of metabolic process. Located in cell surface and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATP5IF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP5IF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP5IF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:27,959,376–27,960,547 | 276.3 kb | Distal (>10kb) Multiome | 711 | |
| chr1:28,088,113–28,088,897 | 147.4 kb | Distal (>10kb) Multiome | 827 | |
| chr1:28,104,959–28,105,483 | 130.9 kb | Distal (>10kb) Multiome | 240 | |
| chr1:28,232,593–28,233,160 | 3.1 kb | Proximal (<10kb) Multiome | 666 | |
| chr1:28,235,692–28,236,588 | 55 bp | At TSS Multiome | 862 | |
| chr1:28,247,126–28,247,685 | 11.2 kb | Distal (>10kb) Multiome | 544 | |
| chr1:28,258,840–28,260,822 | 24.3 kb | Distal (>10kb) Multiome | 910 | |
| chr1:28,369,387–28,370,499 | 133.7 kb | Distal (>10kb) Multiome | 961 | |
| chr1:28,505,412–28,506,885 | 269.8 kb | Distal (>10kb) Multiome | 969 | |
| chr1:28,513,136–28,516,505 | 279.4 kb | Distal (>10kb) Multiome | 461 | |
| chr1:28,517,302–28,519,364 | 282.2 kb | Distal (>10kb) Multiome | 927 |
Genomic view of the ATP5IF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.