The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for PPP1CA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1CA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1CA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,117,553–67,120,314 | 282.8 kb | Distal (>10kb) Multiome | 762 | |
| chr11:67,239,493–67,240,241 | 161.9 kb | Distal (>10kb) Multiome | 792 | |
| chr11:67,265,898–67,267,077 | 135.4 kb | Distal (>10kb) Multiome | 471 | |
| chr11:67,288,260–67,289,971 | 112.7 kb | Distal (>10kb) Multiome | 985 | |
| chr11:67,302,488–67,304,170 | 98.5 kb | Distal (>10kb) Multiome | 661 | |
| chr11:67,316,992–67,318,501 | 84.1 kb | Distal (>10kb) Multiome | 918 | |
| chr11:67,352,967–67,354,228 | 48.2 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,372,171–67,373,596 | 28.8 kb | Distal (>10kb) Multiome | 497 | |
| chr11:67,391,276–67,392,428 | 10.0 kb | Proximal (<10kb) Multiome | 957 | |
| chr11:67,401,038–67,402,351 | 37 bp | At TSS Multiome | 741 | |
| chr11:67,420,418–67,421,666 | 19.4 kb | Distal (>10kb) Multiome | 648 | |
| chr11:67,428,036–67,428,950 | 26.5 kb | Distal (>10kb) Multiome | 813 | |
| chr11:67,443,182–67,444,063 | 41.8 kb | Distal (>10kb) Multiome | 612 | |
| chr11:67,464,410–67,465,252 | 62.9 kb | Distal (>10kb) Multiome | 710 | |
| chr11:67,468,551–67,469,666 | 67.4 kb | Distal (>10kb) Multiome | 774 | |
| chr11:67,482,830–67,483,745 | 81.3 kb | Distal (>10kb) Multiome | 969 | |
| chr11:67,504,073–67,506,408 | 104.5 kb | Distal (>10kb) Multiome HiCAR | 769 | |
| chr11:67,507,504–67,509,030 | 106.5 kb | Distal (>10kb) Multiome HiCAR | 897 | |
| chr11:67,583,474–67,584,777 | 181.9 kb | Distal (>10kb) Multiome | 633 | |
| chr11:67,606,302–67,607,213 | 205.0 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,614,064–67,614,626 | 212.4 kb | Distal (>10kb) Multiome | 383 | |
| chr11:67,619,429–67,620,391 | 218.0 kb | Distal (>10kb) Multiome | 50 | |
| chr11:67,628,876–67,631,242 | 228.5 kb | Distal (>10kb) Multiome | 1018 |
Genomic view of the PPP1CA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.