Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of RNA splicing; negative regulation of intracellular signal transduction; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMBIM6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMBIM6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMBIM6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:49,538,551–49,539,219 | 202.7 kb | Distal (>10kb) Multiome | 284 | |
| chr12:49,550,509–49,551,225 | 190.6 kb | Distal (>10kb) Multiome | 126 | |
| chr12:49,567,505–49,568,696 | 173.4 kb | Distal (>10kb) Multiome | 807 | |
| chr12:49,622,768–49,624,150 | 118.1 kb | Distal (>10kb) Multiome | 788 | |
| chr12:49,706,780–49,708,002 | 34.0 kb | Distal (>10kb) Multiome | 854 | |
| chr12:49,741,069–49,742,357 | 96 bp | At TSS Multiome | 980 | |
| chr12:49,827,122–49,829,288 | 86.9 kb | Distal (>10kb) Multiome | 839 | |
| chr12:49,842,401–49,843,296 | 101.5 kb | Distal (>10kb) Multiome | 806 | |
| chr12:49,866,994–49,867,580 | 125.7 kb | Distal (>10kb) Multiome | 334 | |
| chr12:49,945,408–49,945,886 | 204.2 kb | Distal (>10kb) Multiome | 520 | |
| chr12:49,961,271–49,962,190 | 220.1 kb | Distal (>10kb) Multiome | 164 | |
| chr12:49,966,854–49,967,924 | 225.8 kb | Distal (>10kb) Multiome | 698 | |
| chr12:50,024,956–50,025,990 | 284.0 kb | Distal (>10kb) Multiome | 829 |
Genomic view of the TMBIM6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.