Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TALDO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TALDO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TALDO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:447,919–448,752 | 299.2 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 297.2 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 240.3 kb | Distal (>10kb) Multiome | 977 | |
| chr11:534,525–536,399 | 211.8 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 210.0 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 192.3 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 186.6 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 178.9 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 171.3 kb | Distal (>10kb) Multiome | 793 | |
| chr11:613,334–614,059 | 133.7 kb | Distal (>10kb) Multiome | 215 | |
| chr11:615,262–616,320 | 131.5 kb | Distal (>10kb) Multiome | 443 | |
| chr11:636,786–637,700 | 110.3 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 52.0 kb | Distal (>10kb) Multiome | 873 | |
| chr11:705,737–706,270 | 41.4 kb | Distal (>10kb) Multiome | 361 | |
| chr11:720,619–721,074 | 26.6 kb | Distal (>10kb) Multiome | 156 | |
| chr11:727,901–728,499 | 19.3 kb | Distal (>10kb) Multiome | 686 | |
| chr11:742,144–742,644 | 4.8 kb | Proximal (<10kb) | 58 | |
| chr11:746,704–748,069 | 129 bp | At TSS Multiome | 755 | |
| chr11:762,582–763,602 | 15.8 kb | Distal (>10kb) Multiome | 326 | |
| chr11:776,216–778,328 | 30.0 kb | Distal (>10kb) Multiome | 770 | |
| chr11:783,385–783,909 | 36.3 kb | Distal (>10kb) Multiome | 278 | |
| chr11:797,112–798,675 | 50.8 kb | Distal (>10kb) Multiome | 697 | |
| chr11:804,241–805,812 | 57.9 kb | Distal (>10kb) Multiome | 725 | |
| chr11:808,894–810,402 | 62.3 kb | Distal (>10kb) Multiome | 976 | |
| chr11:818,369–820,592 | 72.1 kb | Distal (>10kb) Multiome | 749 | |
| chr11:826,980–828,116 | 80.1 kb | Distal (>10kb) Multiome | 662 | |
| chr11:828,933–831,262 | 82.9 kb | Distal (>10kb) Multiome | 491 | |
| chr11:832,323–833,565 | 85.4 kb | Distal (>10kb) Multiome | 562 | |
| chr11:842,034–843,556 | 95.2 kb | Distal (>10kb) Multiome | 794 | |
| chr11:843,773–845,220 | 97.0 kb | Distal (>10kb) Multiome | 664 | |
| chr11:849,082–850,270 | 102.3 kb | Distal (>10kb) Multiome | 229 | |
| chr11:910,337–911,591 | 163.5 kb | Distal (>10kb) Multiome | 754 | |
| chr11:925,038–926,264 | 178.4 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the TALDO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.