CSNK2B
casein kinase 2 beta | Ckb1, Ckb2

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Member of: DE-1 DE-1.12
Biological processes 47 terms
PML body (GO:0016605)PcG protein complex (GO:0031519)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)adiponectin-activated signaling pathway (GO:0033211)chromatin (GO:0000785)chromatin (GO:0000785)chromatin binding (GO:0003682)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)endothelial tube morphogenesis (GO:0061154)extracellular exosome (GO:0070062)extracellular region (GO:0005576)fibrillar center (GO:0001650)ficolin-1-rich granule lumen (GO:1904813)heterochromatin formation (GO:0031507)identical protein binding (GO:0042802)negative regulation of blood vessel endothelial cell migration (GO:0043537)negative regulation of cell population proliferation (GO:0008285)negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)negative regulation of viral life cycle (GO:1903901)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of SMAD protein signal transduction (GO:0060391)positive regulation of activin receptor signaling pathway (GO:0032927)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein kinase CK2 complex (GO:0005956)protein kinase CK2 complex (GO:0005956)protein kinase CK2 complex (GO:0005956)protein kinase CK2 complex (GO:0005956)protein kinase regulator activity (GO:0019887)protein kinase regulator activity (GO:0019887)protein kinase regulator activity (GO:0019887)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein-containing complex assembly (GO:0065003)protein-macromolecule adaptor activity (GO:0030674)secretory granule lumen (GO:0034774)signal transduction (GO:0007165)signaling receptor binding (GO:0005102)symbiont-mediated disruption of host cell PML body (GO:0075342)
Expression (TPM)
CSNK2B — as a Regulated Gene

TFs regulating CSNK2B 0 TFs

Transcription factors with Perturb-seq knockdown data for CSNK2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSNK2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CSNK2B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSNK2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:31,366,884–31,367,398 299.0 kb Distal (>10kb) Multiome 433
chr6:31,399,631–31,400,231 266.2 kb Distal (>10kb) Multiome 678
chr6:31,403,046–31,404,269 262.5 kb Distal (>10kb) Multiome 796
chr6:31,441,682–31,442,105 224.3 kb Distal (>10kb) Multiome 316
chr6:31,462,703–31,463,323 203.0 kb Distal (>10kb) Multiome 352
chr6:31,497,638–31,498,615 168.1 kb Distal (>10kb) Multiome 613
chr6:31,541,205–31,542,816 124.0 kb Distal (>10kb) Multiome 1073
chr6:31,546,485–31,547,136 119.3 kb Distal (>10kb) Multiome 589
chr6:31,547,301–31,547,742 118.5 kb Distal (>10kb) Multiome 762
chr6:31,580,713–31,581,330 85.0 kb Distal (>10kb) Multiome 745
chr6:31,619,744–31,621,435 45.5 kb Distal (>10kb) Multiome 1127
chr6:31,651,682–31,653,297 13.4 kb Distal (>10kb) Multiome 1113
chr6:31,660,325–31,660,941 5.3 kb Proximal (<10kb) Multiome 892
chr6:31,664,725–31,666,373 1.2 kb Proximal (<10kb) Multiome 1039
chr6:31,682,887–31,683,880 17.3 kb Distal (>10kb) Multiome 248
chr6:31,702,816–31,703,520 37.2 kb Distal (>10kb) Multiome 875
chr6:31,713,576–31,714,641 48.1 kb Distal (>10kb) Multiome 171
chr6:31,728,852–31,730,814 64.2 kb Distal (>10kb) Multiome 979
chr6:31,739,236–31,740,741 73.8 kb Distal (>10kb) Multiome 1043
chr6:31,766,045–31,766,778 100.4 kb Distal (>10kb) Multiome 351
chr6:31,795,097–31,796,366 129.9 kb Distal (>10kb) Multiome 979
chr6:31,806,162–31,807,183 140.9 kb Distal (>10kb) Multiome HiCAR 947
chr6:31,814,125–31,815,936 148.5 kb Distal (>10kb) Multiome 822
chr6:31,818,020–31,818,663 152.3 kb Distal (>10kb) Multiome 280
chr6:31,821,306–31,822,544 155.9 kb Distal (>10kb) Multiome HiCAR 714
chr6:31,826,770–31,828,135 161.4 kb Distal (>10kb) Multiome HiCAR 1000
chr6:31,834,277–31,835,371 168.6 kb Distal (>10kb) Multiome HiCAR 1085
chr6:31,862,148–31,864,173 196.8 kb Distal (>10kb) Multiome HiCAR 1118
chr6:31,896,965–31,898,037 231.5 kb Distal (>10kb) Multiome 654
chr6:31,901,114–31,902,643 236.2 kb Distal (>10kb) Multiome 826
chr6:31,958,527–31,959,598 293.0 kb Distal (>10kb) Multiome 953

Genome Browser

Genomic view of the CSNK2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:31,356,884 – 31,969,598
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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