PHB2

prohibitin 2 | BCAP37, Bap37, REA, p22

Enables amide binding activity; protein dimerization activity; and sphingolipid binding activity. Involved in several processes, including RIG-I signaling pathway; positive regulation of cell cycle phase transition; and regulation of DNA-templated transcription. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-1 DE-1.12

Biological processes 64 terms

B cell activation (GO:0042113)B cell activation (GO:0042113)RIG-I signaling pathway (GO:0039529)RIG-I signaling pathway (GO:0039529)antiviral innate immune response (GO:0140374)antiviral innate immune response (GO:0140374)binding (GO:0005488)cell migration (GO:0016477)cell periphery (GO:0071944)cell surface (GO:0009986)cell surface (GO:0009986)cytoplasm (GO:0005737)cytoplasm (GO:0005737)identical protein binding (GO:0042802)inner mitochondrial membrane protein complex (GO:0098800)membrane (GO:0016020)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial outer membrane (GO:0005741)mitochondrial prohibitin complex (GO:0035632)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)mitophagy (GO:0000423)mitophagy (GO:0000423)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of apoptotic process (GO:0043066)nuclear estrogen receptor binding (GO:0030331)nuclear matrix (GO:0016363)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of MAPK cascade (GO:0043410)positive regulation of immunoglobulin production (GO:0002639)positive regulation of immunoglobulin production (GO:0002639)positive regulation of non-canonical NF-kappaB signal transduction (GO:1901224)positive regulation of non-canonical NF-kappaB signal transduction (GO:1901224)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein import into nucleus (GO:0006606)protein stabilization (GO:0050821)protein stabilization (GO:0050821)protein-containing complex (GO:0032991)regulation of cardiolipin metabolic process (GO:1900208)regulation of cardiolipin metabolic process (GO:1900208)regulation of complement activation (GO:0030449)regulation of transcription by RNA polymerase II (GO:0006357)sister chromatid cohesion (GO:0007062)sphingolipid binding (GO:0046625)sphingolipid binding (GO:0046625)

Expression (TPM)

TFs regulating PHB2 0 TFs

Transcription factors with Perturb-seq knockdown data for PHB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PHB2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr12:6,688,517–6,690,027	281.2 kb	Distal (>10kb) Multiome	943
chr12:6,699,959–6,700,887	270.2 kb	Distal (>10kb) Multiome	263
chr12:6,723,658–6,724,773	246.6 kb	Distal (>10kb) Multiome	1065
chr12:6,752,554–6,754,332	217.2 kb	Distal (>10kb) Multiome	975
chr12:6,763,677–6,764,983	206.3 kb	Distal (>10kb) Multiome	570
chr12:6,765,172–6,767,791	204.3 kb	Distal (>10kb) Multiome	824
chr12:6,768,329–6,769,331	201.6 kb	Distal (>10kb) Multiome	249
chr12:6,778,736–6,779,459	191.6 kb	Distal (>10kb) Multiome	777
chr12:6,821,268–6,822,155	148.9 kb	Distal (>10kb) Multiome	299
chr12:6,825,458–6,825,915	145.0 kb	Distal (>10kb) Multiome	404
chr12:6,828,101–6,829,966	141.1 kb	Distal (>10kb) Multiome	689
chr12:6,851,017–6,853,279	118.3 kb	Distal (>10kb) Multiome	966
chr12:6,866,801–6,870,175	103.2 kb	Distal (>10kb) Multiome	887
chr12:6,871,062–6,874,199	98.3 kb	Distal (>10kb) Multiome	947
chr12:6,890,735–6,891,820	79.5 kb	Distal (>10kb) Multiome	908
chr12:6,904,217–6,905,282	65.8 kb	Distal (>10kb) Multiome	566
chr12:6,914,274–6,914,898	56.2 kb	Distal (>10kb) Multiome	536
chr12:6,924,156–6,924,592	46.2 kb	Distal (>10kb) Multiome	458
chr12:6,925,828–6,926,431	44.7 kb	Distal (>10kb) Multiome	407
chr12:6,927,411–6,928,051	42.8 kb	Distal (>10kb) Multiome	493
chr12:6,936,709–6,938,342	32.6 kb	Distal (>10kb) Multiome	1008
chr12:6,942,356–6,945,492	26.5 kb	Distal (>10kb) Multiome	1205
chr12:6,945,587–6,947,099	24.2 kb	Distal (>10kb) Multiome	618
chr12:6,961,769–6,963,542	7.5 kb	Proximal (<10kb) Multiome	682
chr12:6,964,932–6,965,569	5.4 kb	Proximal (<10kb) Multiome	549
chr12:6,970,111–6,971,189	90 bp	At TSS Multiome	899
chr12:7,018,028–7,019,126	48.0 kb	Distal (>10kb) Multiome HiCAR	824
chr12:7,108,059–7,109,582	138.6 kb	Distal (>10kb) Multiome	818
chr12:7,129,788–7,131,412	159.6 kb	Distal (>10kb) Multiome	619
chr12:7,188,394–7,190,508	217.9 kb	Distal (>10kb) Multiome	769

Genome Browser

Genomic view of the PHB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.