GC6

Gene Cluster 998 genes

Cell motility and migration signaling

This 1040-gene module includes AKT1, HLA-DRB1, CXCR4, IGF1R, and MAPK3, with enrichment in cell motility, cell migration, and plasma membrane bounded cell projection organization. Knockdown of ARID1A activates this module. Knockdown of FOXA2 and HNF1B represses this module.

Key terms: cell motility cell migration cellular developmental process cell differentiation cell surface receptor signaling pathway Notable genes: AKT1 HLA-DRB1 CXCR4 IGF1R MAPK3 KIT AGER CDKN1B Top TFs: ARID1A SMARCC1 MIXL1 SMAD3 SMAD5

998 member genes 116 TF regulators

TF Regulatory Network

Direction indicates the effect of TF knockdown on this gene cluster (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	padj	Bind	OR

Module Genes

Genes assigned to this temporal expression cluster (mfuzz).

Gene	Type	Publications