GC5

Gene Cluster 1016 genes

Protein synthesis and oxidative energy metabolism

This 1,037-gene module includes SIRT1, MET, SOD1, FGFR1, and SOX2, and is enriched for protein biosynthetic process, translation, and oxidative phosphorylation. Knockdown of SOX17 and DNAJC19 activates this module. Knockdown of SMARCC1 represses this module.

Key terms: protein biosynthetic process translation oxidative phosphorylation mitochondrial translation ATP synthesis coupled electron transport Notable genes: SIRT1 MET SOD1 FGFR1 SOX2 IGFBP3 TNFSF11 MSH2 Top TFs: SMARCC1 CNBP DNAJC19 AFF1 AFF4

1016 member genes 707 TF regulators

TF Regulatory Network

Direction indicates the effect of TF knockdown on this gene cluster (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	padj	Bind	OR

Module Genes

Genes assigned to this temporal expression cluster (mfuzz).

Gene	Type	Publications